近视散光眼在自然扩瞳和药物散瞳后波面像差的研究  

The Study of the Difference between Wavefront Aberrations of AstigmaticMyopia Measured in Dark and with Mydriatic

作　　者：李琪[1] 任秋实[1] 李颖[1] 

机构地区：[1]上海交通大学激光与生物医学光子生物医学研究所,中国上海200030

出　　处：《激光生物学报》2005年第1期1-7,共7页Acta Laser Biology Sinica

摘　　要：目的 :讨论近视散光眼人群在暗室自然扩瞳和使用药物散瞳后所得到波面像差的差别。方法 :使用基于Shack Hartmann原理设计的COAS(completeophthalmicanalysissystem)波面像差仪检查 6 2只眼 ,分别在暗室自然扩瞳和通过滴加美多丽 P散瞳液后的波面像差。并使用COAS波面像差仪自带软件分别计算在三个分析瞳孔尺寸下的二～六阶像差系数。运用双因素方差分析 (twowayANOVA)方法研究各阶均方根 (rootmeansquare ,RMS)和各种类型像差在药物作用和分析瞳孔尺寸这两个因素影响下的变化是否具有显著性 ,同时考虑二因素的交互作用。结果 :药物散瞳对二、三阶像差均方根的影响没有显著意义 (P >0 .10 ) ,但在测量更高阶像差———四、五、六阶时 ,与暗室自然扩瞳所得波面像差的差异具有显著性意义 ;虽然不同瞳孔尺寸对各阶波面像差均方根变化具有显著意义 (P <0 .0 1) ,但对研究药物散瞳对波面像差的影响无显著意义 (P >0 .10 )。结论 :药物散瞳与暗室自然扩瞳在高阶像差测量时的差异均有显著意义 。Objective: To investigate the difference between wavefront measurements in dark and after dilated with mydriatic of the myopic with astigmatism. Methods: Using COAS(Complete Ophthalmic Analysis System)based on Shack-Hartmann technology, we measured 62 eyes in dark with and without mydriatic respectively. Then recomputed wavefront aberrations at different optical zones and the 2^(nd) to 6^(th) order aberrations were analyzed. We chose Two way ANOVA to test whether mydriatic and different analyzing optical zones will lead the the root mean square and every type of aberrations of each order to show significant differences, in the mean time, we considered the interaction between mydriatic and its optical zones. Results: The RMS difference of 2^(nd) and 3^(rd) order caused by mydriatic is not significant (P>0.10), while RMS difference of 4th to 6th order caused by it is statistically significant (P<0.05). Different analyzing pupil sizes changed each order RMS remarkably (P<0.01), but had little effects on analyzing mydriatic's influence on ocular aberrations (P>0.10). The effect of two factors on results varies among aberrations. Conclusions: The difference between wavefront measurement in dark and with mydriatic is statistically significant in 4th to 6th order aberrations in various analyzing pupil sizes, and it is suggested to take wavefront measurements in dark in clinic application.

关 键 词：扩瞳 近视 散光 波面像差 

分 类 号：R778[医药卫生—眼科]