外伤性aPVR引起慢性低眼压的房水动力学研究  

Study of aqueous humor dynamics in chronic hypotony induced by traumatic anterior proliferative vitreoretinopathy

作　　者：刘百臣[1] 张卯年[2] 刘铁城[2] 彭秀军[1] 

机构地区：[1]海军总医院眼科,北京100037 [2]解放军总医院眼科

出　　处：《解放军医学杂志》2005年第2期104-106,共3页Medical Journal of Chinese People's Liberation Army

基　　金：全军"十五"医学科研面上项目资助课题 (编号 0 1MA1 1 3)

摘　　要：目的　探讨外伤性前部增生性玻璃体视网膜病变 (aPVR)低眼压状态下的房水生成率、流出率变化 ,从房水动力学的角度揭示外伤性aPVR引起慢性低眼压的发病机制。方法　制作兔外伤性aPVR引起慢性低眼压的动物模型。于术前及术后 2、4、8周分别测定房水生成率及房水经葡萄膜巩膜流出量 (Fu)。结果　术后 2、4、8周实验组房水生成率均明显低于对照组 (P <0 0 5或P <0 0 1) ,术后 2周 ,实验组和对照组Fu无明显差别 ,术后 4周、8周实验组Fu明显高于对照组。结论　外伤性aPVR低眼压的形成与房水生成率下降及Fu增加有关。Objective To study the dynamics of aqueous humor in chronic hypotony induced by traumatic anterior proliferative vitreoretinopathy (aPVR), and to demonstrate physiologic mechanisms of the hypotony. Methods A model of hypotony to simulate traumatic aPVR was reproduced in rabbits. Preoperatively and on day 7, 14, 28 and 56 postoperatively, the aqueous humor flow rate and the uveoscleral outflow of aqueous humor were determined. Results The flow rate of aqueous humor in experimental group was reduced remarkably compared with that of control group on days 14, 28 and 56 (P<0.01). Two weeks postoperatively, the uveoscleral outflow of aqueous humor in experimental and control groups was similar, but it was greater than that in normal group remarkably. Four and eight weeks postoperatively, the uveoscleral outflow of aqueous humor in the experimental group was significantly greater than that in control group. Conclusions The hypotony in traumatic aPVR was associated with a decrease in aqueous humor flow rate and with an increase in uveoscleral outflow of aqueous humor.

关 键 词：外伤性 前部增生性玻璃体视网膜病变 低眼压 房水动力学 

分 类 号：R774[医药卫生—眼科]