石英致癌的细胞及分子机制研究进展  

Cellular and Molecular Mechanisms of Carcinogenesis of Quartz Dust

作　　者：王德军[1] 杨跃林[1] 王绵珍[1] 罗素琼[1] 

机构地区：[1]四川大学华西公共卫生学院劳动卫生教研室,成都610041

出　　处：《环境与职业医学》2005年第1期60-62,共3页Journal of Environmental and Occupational Medicine

摘　　要：关于石英的致癌性 ,国际上争论了几十年 ,国际癌症研究中心 (IARC)终于于 1996年 10月正式宣布石英为人类致癌物 ,但尚缺乏DNA水平的直接证据。本文对近年来有关石英致癌机制方面的文献进行综述 ,包括对SiO2 诱导的肺泡上皮细胞的转化与增殖、肺泡上皮细胞间隙通讯功能下调、SiO2 介导的DNA损伤与修复、活性氧自由基对靶细胞的作用。The argument about the carcinogenesis of quartz had lasted for many years. IARC eventually proclaimed that quartz as a cancerogen for human beings. But it is lack of directly DNA-level evidences. This article summarized the literature about carcinogenic mechanisms of quartz in recent years. It explained cellular and molecular mechanisms of quartz dust inducing cancer about transformation and proliferation of alveolar epithelium cells,down-regulation of GJIC function,damage and repair of DNA induced by SiO 2,action of oxygen-derived free radicals on target cells,quartz and tumor-related gene etc.

关 键 词：肺泡上皮细胞 分子机制 致癌机制 制方 研究进展 肿瘤相关基因 靶细胞 DNA水平 缺乏 活性氧自由基 

分 类 号：R730[医药卫生—肿瘤] R135.2[医药卫生—临床医学]