海洛因成瘾复吸大鼠脑组织超微结构和部分神经递质的变化  

Changes of nervous tissue ultrastructures and neurotransmitter in brain of heroin re-addicted rats

作　　者：叶峻[1] 韦献良[1] 韦世秀[2] 蒙子卿[2] 刘佳娟[3] 梁莹[4] 

机构地区：[1]广西医科大学解剖学教研室,南宁530021 [2]广西医科大学医学实验中心,南宁530021 [3]广西医科大学科研处,南宁530021 [4]广西医科大学电镜室,南宁530021

出　　处：《解剖学杂志》2004年第6期624-629,共6页Chinese Journal of Anatomy

基　　金：广西科学研究与技术开发计划项目 (桂科攻 0 0 15 0 5 0 );广西教育厅科研项目 (2 0 0 3年 );教育部"春晖计划"项目 (2 0 0 4年 )

摘　　要：目的 :建立海洛因成瘾、脱毒 ,复成瘾、脱毒 ,再成瘾、脱毒 3个阶段大白鼠模型 ,了解海洛因致各阶段大白鼠脑损害的动态趋势。方法 :电镜下观察脑超微结构变化 ,荧光分光度法测定脑NA、DA、5 HT等神经递质的含量。结果 :3个阶段大鼠脑内多部位神经元胞体、轴突、树突都出现变性、凋亡、胀亡等超微病理结构改变 ,神经胶质细胞、神经毯也出现相应的超微病理结构改变 ,而且随复吸次数增多而病变加重。脑NA、DA、5 HT、含量升高 ,而且随复吸次数增多而升高。结论 :大白鼠脑组织出现广泛性超微病理结构改变 ,随复吸次数增多而病变加重 。Objective: To set up heroin addiction and readdiction model with the processes of heroin addiction→abstension treatment of heroin→heroin readdiction→reabstension treatment of heroin→heroin addiction a third time →abstension treatment of heroin a third time,and make clear the dynamic trend of the brain lesions. Methods:The changes of brain ultrastructures were observed under electron microscope and the changes of neurotransmitter such as NA, DA, 5-HT were analysed by means of fluorescence microspectro-photometry. Results: Degeneration, apoptosis and oncosis were found in the neuronal somas, axons, dendrites of the heroin addicted and readdicted rats' brains from all periods. Pathological changes of ultrastructures were found in the neuroglial cell and the neuropil.It showed the trend of aggravating by periodical pathological change. The changes of NA, DA,5-HT from the heroin addicted rats of all periods increased and it showed the trend of increasing with the increase of readdicting times. Conclusion: Widespread lesions have been found and were more severe with readdicted times. The neurotransmitters show pathological changes accordingly.

关 键 词：复吸 超微病理 海洛因成瘾 脑组织 升高 神经递质 大鼠 脱毒 病变 次数 

分 类 号：R749.6[医药卫生—神经病学与精神病学]