抑郁症患者吸烟对马普替林治疗作用的影响  

Smoking patients with depression have an influence on the therapeutic effect of maprotiline.

作　　者：安庆华[1] 罗维玲[1] 李从梅[1] 

机构地区：[1]山东省滨州市人民医院精神卫生中心,256613

出　　处：《四川精神卫生》2005年第1期25-26,共2页Sichuan Mental Health

摘　　要：目的　探讨抑郁症患者吸烟对马普替林治疗剂量、疗效和不良反应的影响。方法　对 12 0例符合CCMD - 3诊断标准的抑郁症患者 ,采用HAMD量表减分率评价其临床疗效 ,用TESS评定其安全性。对吸烟和不吸烟的抑郁症患者进行马普林治疗剂量、疗效和不良反应的比较。结果　吸烟的抑郁症患者所服马普替林日平均剂量显著高于不吸烟的患者、疗效显著差于不吸烟患者 ,不良反应显著轻于不吸烟患者。结论　抑郁症患者在马普替林治疗期间少吸烟或不吸烟 ,可以减少马普替林的用量和提高疗效。Objective To study the influence between smoking and t herapeutic dosage,side effects of maprotiline in depressive patients. Methods 120 inpatients who met criteria of depression in CCMD-3 were adopted.The clinical effect was evaluated by reduced rate of HAMD.The safety wa s evaluated by TESS.The dosage,therapeutic efficacy and side effects of maprotil ine in smoking patients were compared with nonsmoking patients.Result s The effective dosage of maprotiline was higher in smoking patients than in nonsmoking patients,the efficacy was more significantly in nonsmoking p atients.Conclusion During treatment with maprotiline,smok ing should be forbidden as far as possible in depression.This procedure can decr ease dosage of maprotiline and enhance the effect of maprotiline. [

关 键 词：抑郁症 马普替林 吸烟 

分 类 号：R749.4[医药卫生—神经病学与精神病学]