司氟沙星CHL细胞体外染色体畸变试验  

Effects of sparfloxacin on chromosome aberration of CHL cell in vitro

作　　者：刘尚裕[1] 宋坤改[1] 林赴田[1] 郭惠元[1] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所,北京100050

出　　处：《中国新药杂志》2004年第12期1114-1116,共3页Chinese Journal of New Drugs

摘　　要：目的:检测司氟沙星对CHL细胞染色体致畸变作用。方法:用体外方法检测司氟沙星在23.63～189.00μg·mL^(-1)浓度范围内,代谢活化组(含S_9mix)及非活化组(不含S_9mix)CHL 细胞的染色体畸变率。结果:司氟沙星的代谢活化组(含S_9mix)及非活化组(不含S_9mix)的染色体畸变率均低干5%。结论:司氟沙星对CHL 细胞染色体畸变实验结果为阴性。Objective:To assess whether sparfloxacin causes the chromosome aberration.Meth-ods:At the concentrations of 23.63～189.00μg·mL^(-1),the mutagenicity of sparfloxacin on Chinesehamster lung cell in the presence and absence of the liver homogenate fraction (S_9mix) in vitro was e-valuated.Results:Sparfloxacin achieved a chromosome aberration of less than 5% in the presence andabsence of S_9mix.Conclusion:Sparfloxacin has not demonstrated effects on chromosome aberration.

关 键 词：司氟沙星 中国仓鼠肺细胞 染色体畸变 

分 类 号：R965.3[医药卫生—药理学] R978[医药卫生—药学]