bcl-2在胃肠道间质瘤中的表达  

Expression of bcl-2 in Gastrointestinal Stromal Tumors

作　　者：鲁常青[1] 谈敏[1] 李青[1] 陈同钰[1] 谈炎[1] 曹留斌[1] 

机构地区：[1]苏州大学附属三院 病理科,江苏常州213003

出　　处：《苏州大学学报（医学版）》2004年第6期858-860,共3页Suzhou University Journal of Medical Science

摘　　要：目的 研究胃肠道间质瘤(GIST)中bcl-2的表达及其意义。方法 应用免疫组化Envision二步法检测bcl-2、CD 117、CD 34等在肿瘤中的表达。结果 51例GIST中,CD 117和CD 34阳性表达率分别为100％和76.5％;bcl-2阳性45例,阳性率为88.2％,其中良性、潜在恶性及恶性GIST中,bcl-2阳性表达率分别为100％、91.7％、82.8％,bcl-2阳性表达率与GIST良恶性无显著性差异(P>0.05)。结论bcl-2蛋白可作为诊断GIST的辅助性标记物之一,但不能作为判断GIST良恶性的指标。Objective To investigate the expression of bcl-2 in gastrointestinal stromal tumors (GIST). Methods The expression of bcl-2, CD 117 and CD 34 were detected in 51 cases of GIST with Envision immunohistochemical method. Results In 51 GIST, the positive rates of CD 117 and CD 34 were 100 % and 76. 5 % . The expression of bcl-2 were observed in 45 of 51 cases (88.2 % ), and the positive rates of the benign, borderline and the malignant GIST were 100%, 91. 7% and 82. 8% respectively. There was no significant difference in expression of bcl-2 between the benign GIST and malignant GIST. Conclusion Bcl-2 may serve as a supplemental marker of GIST for diagnosis, which may not be used as the index to distinguish the benign GIST from the malignant GIST.

关 键 词：胃肠道间质瘤 BCL-2蛋白 免疫组织化学 

分 类 号：R735.204[医药卫生—肿瘤] R735.304[医药卫生—临床医学]