“消癃通闭”对犬大脑皮层α_1肾上腺素受体的拮抗作用  

Antagonism of XLTB on a1-adrenalin Receptor in Canine Cerebral Cortex

作　　者：贾金铭[1] 孙利民[1] 马春涛[1] 吕志珍[2] 李寅增[2] 韩启德[2] 

机构地区：[1]中国中医研究院广安门医院,100053 [2]北京医科大学

出　　处：《现代泌尿外科杂志》2000年第1期1-3,共3页Journal of Modern Urology

基　　金：国家自然基金(39270856)

摘　　要：不同浓度的“消癃通闭”浸出液与犬大脑皮层粗制膜及IBE^(125)作用,测定“消癃通闭”对IBE^(125)与犬大脑皮层α_1-AR结合的抑制作用。结果显示“消癃通闭”对IBE^(125)犬大脑皮层的结合呈竞争性拮抗作用,IC_(50)为34.0±6.0g/L,Hill系数为0.70±0.06。佐证本方剂具有α_1-AR拮抗作用。The inhibition of XLTB(Xiao-Long-Tong-Bi) on the combination between 125IBE and a1-a-drenalin receptor (a1-AR) in canine cerebral cortex was studied. Results: The competitive antagonism of XLTB on combination on 125IBE and α1-AR in canine cerebral cortex was showed. IC50 was 34. 0±6.0g/L. Hill coefficient was 0. 70±0. 06. The antagonism of XLTB on α1-AR was proved.

关 键 词：大脑皮层 Α1-肾上腺素受体 拮抗作用 AR 方剂 抑制作用 浸出液 竞争性 

分 类 号：R977[医药卫生—药品]