鼻咽癌局部复发分次立体定向放射治疗  

Fractionated 3-Dimensional Stereotactic Radiotherapy for Locally Recurrent Nasopharyngeal Carcinoma

作　　者：敖帆[1] 周毅[1] 廖瑜露[1] 李金高[1] 邬蒙[1] 

机构地区：[1]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2004年第5期530-532,共3页The Practical Journal of Cancer

摘　　要：目的　探讨分次立体定向放射治疗技术 ,在局部复发晚期鼻咽癌再程放疗中的应用。方法　 1997年 7月到 2 0 0 0年12月 ,采用分次立体定向放射治疗局部复发鼻咽癌 2 3例。所有病例均采用 6MVX线照射 ,设 1～ 3个中心 ,80 %剂量曲线将靶区完全包含。总剂量DT2 4～ 64Gy(中位剂量 5 2 .2Gy) ,单次剂量DT4～ 8Gy(中位剂量 6.4Gy)。 结果　局部复发鼻咽癌经分次立体定向放射治疗后 ,1年生存率为 78.3 % (18/2 3 )、2年生存率为 69.6% (16/2 3 )。 3 9.1% (9/2 3 )的患者随访期内死亡 ,其中死于局部复发 1例 ,死于远处转移 5例 ,鼻咽大出血 3例。结论　分次立体定向放射治疗用于局部复发鼻咽癌的治疗是安全有效的 ,但单次剂量和总剂量值得进一步研究。Objective To evaluate the clinical application of fractionated 3-dimensional stereotatic radiotherapy in the treatment of patients with locally recurrent nasopharyngeal carcinoma(NPC).Methods From July 1997 to December 2000,23 patients with locally recurrent nasopharyngeal carcinoma were treated with fractionated 3-dimensional stereotactic radiotherapy using 6MV X-rays.The irradiation was performed at one to three centers on the 80% isodose curves normalized to the isocenter.The total dose was 24～64 Gy(median dose:52.5 Gy) with a fraction dose of 4～8 Gy(median dose 6.4 Gy).Results The overall rate of survival was 78.3% at 1 year,69.6% at 2 year.39.1% of the patients were died during the follow-up period due to local recurrence(1 case),distant metastases(5 cases),and fatal nasopharyngeal hemorrhage(3 cases).Conclusion Fractionated 3-dimensional stereotactic radiotherapy is safe and effective in the treatment of patients with recurrent nasopharyngreal carcinoma at the primary site,but the fraction and total doses require further investigation.

关 键 词：鼻咽癌 分次剂量 立体定向 放射治疗 

分 类 号：R739.62[医药卫生—肿瘤]