左旋肉碱对维持性血液透析患者胰岛素抵抗的影响  

The effect of L-carnitine on insulin resistance in patients undergoing hemodialysis

作　　者：孙倩美[1] 沈洋[1] 彭立人[1] 

机构地区：[1]首都医科大学附属北京朝阳医院,北京100020

出　　处：《中国血液净化》2005年第2期77-78,共2页Chinese Journal of Blood Purification

摘　　要：目的　观察左旋肉碱对维持性血液透析患者胰岛素抵抗 (IR)的影响。方法　选择尿毒症维持血液透析患者 4 0例 ,随机分成 2组 ,治疗组 2 0例、对照组 2 0例 ,治疗组于每次透析后静脉注射左旋肉碱1.0g,对照组静脉注射 5ml生理盐水 ,疗程共 12周。另设正常对照组 10例。用空腹血糖与空腹胰岛素浓度乘积的倒数即胰岛素敏感指数 (ISI)作为胰岛素敏感指标。采用放免法测定胰岛素水平。常规方法检测总胆固醇、甘油三脂等指标。结果　治疗组肉碱治疗 12周后患者ISI较治疗前显著提高 (P <0 .0 5 )。对照组ISI无显著性变化。结论　维持性血液透析患者存在IR现象 ,左旋肉碱能改善维持性血液透析患者IR。Objective To investigate the effect of L-carnitine on insulin resistance in patients undergoing hemodialysis. Methods Forty patients undergoing hemodialysis were randomly div ided into 2 groups. The therapy group were intravenously infused 1.0g of L-carni tine after every dialysis session; Control group were intravenously given 5ml sa line. The reverse of fasting plasma glucose and insulin concentration product we re used as index of insulin resistance. We observed for 12 weeks. Results In therapy group,the index of insulin resistance was sig nificantly increased (P < 0.05) while No significant change was found in control group. Conclusion There is the presence of IR in patients undergoing he modialysis; L-carnitine may improve the insulin resistance of hemodialysis patie nts.

关 键 词：尿毒症 胰岛素抵抗 肉碱 

分 类 号：R453[医药卫生—治疗学]