慢性胃病中几种胃肠激素水平的改变  

The Change on the Level of Some Gastrointestinal Hormones in Gastric Juice or Serum in Patients with Gastroduodenal Diseases

作　　者：蔡立勉[1] 潘秀珍[1] 吴平[1] 

机构地区：[1]福建省立医院消化病研究室

出　　处：《现代诊断与治疗》1993年第2期117-119,156,共4页Modern Diagnosis and Treatment

基　　金：福建省卫生厅青年科研基金

摘　　要：用RIA法测定352例胃镜病理诊断的胃、十二指肠病患者之胃液或血清表皮生长因子(EGF)、生长抑素(SS)和胃泌素(GAS)水平。结果表明,胃液EGF水平在胃癌明显升高,在消化性溃疡降低;血清SS及GAS水平在各种胃、十二指肠病中均显著高于正常对照,溃疡病的血清SS和GAS呈负相关趋势。各种胃病血清SS水平相近,胃液SS水平胃癌显著高于良性胃病,且胃癌胃液SS显著高于其血清SS水平。幽门螺杆菌(HP)感染不影响溃疡病的血清GAS和SS水平及慢性浅表性胃炎的血清SS水平,HP感染严重时慢性萎缩性的血清SS水平升高显著。The gastric juice or serum was studied by RIA for their level of epidermal growth factor (EGF), somatostation(SS)and gastrin (GAS) in 352 cases with gastrod(?)denol diseases. The EGF level in gastric juice obviously elevate in gastric cancer and lower in pep(?) ulcer. The serum SS or GAS level was significantly higher in chronic gastritis and peptic ulcer than in normal control. There was negative correlation trend between the levels of serum SS and GAS in peptic ulcer(p<0.025). In gastric cancer, SS level of gastric juice was significantly higher than that of serum, but in other groups, they are similar in value. Moreover, SS level of gastric juice was significantly higher in gastric cancer than that in benign diseases. The results of Helicobacter Pylori Urea Test(HPUT) showed that no HP effects was found on serum SS or GAS level in peptie ulcer and on serum SS level in chronic superficial gastritis. In chronic atrophic gastritis, serum SS level of HPUT severe possitivity cases was significantly or obiviously higher than that of negative or mild possitivity eases.

关 键 词：胃肿瘤 胃溃疡 胃肠道激素 

分 类 号：R735.203[医药卫生—肿瘤]