偏最小二乘法测定复方乙酰水杨酸片中的有效成分  

DETERMINATION OF THE ACTIVE COMPONENTS OF COMPOUND ASPIRIN TABLETS BY PLS METHOD

作　　者：王桂芳[1] 李光和[2] 窦英[3] 任玉林[3] 

机构地区：[1]白城医学院,白城137000 [2]白城市药品检验所,白城137000 [3]吉林大学化学学院,长春130021

出　　处：《化学分析计量》2005年第1期40-42,共3页Chemical Analysis And Meterage

摘　　要：将偏最小二乘法 (PLS)与近红外漫反射光谱法相结合 ,对复方乙酰水杨酸片进行无损非破坏定量分析 ,建立了最佳的数学校正模型 ,比较了样品中 3种有效成分 (乙酰水杨酸、非那西丁和咖啡因 )同时测定和单独测定时的主成分数对PLS定量预测能力的影响 ,预测了未知样品。 3种有效成分同时测定和单独测定建立的PLS模型具有相同的主成分数 ,PLS预报浓度与参考浓度具有相近的标准偏差 ,说明用PLS法同时测定 3种组分的含量是可行的。The application of PLS (partial least squares) and near infrared spectroscopy for compound aspirin tablets non destructive quantitative analysis was investigated and the best mathematic calibration models were built. The results of three active components in tablets (aspirin, phenacetin and caffeine) determined synchronously were compared with which determined separately. There are the same number of factors in the methods determined synchronously and separately, in the meantime the standard deviations of prediction concentration are similar to that of reference concentration. Therefore the method to determine three active components synchronously using PLS is feasible.

关 键 词：PLS 有效成分 复方 乙酰水杨酸 同时测定 近红外漫反射光谱法 咖啡因 分数 数学 学校 

分 类 号：O657[理学—分析化学] R284[理学—化学]