吉西他滨超液化碘油乳剂治疗晚期肝肿瘤初步研究  

Initial study on gemcitabine with lipiodol emulsion in the treatment of advance dliver cancer

作　　者：吴熙中[1] 严江[2] 陈艳萍[2] 刘国瑞[1] 

机构地区：[1]汕头大学医学院第二附属医院放射科,广东汕头515041 [2]汕头大学医学院第一附属医院肿瘤外科,广东汕头515041

出　　处：《中国癌症杂志》2005年第1期75-76,共2页China Oncology

摘　　要：　　　目的:探讨吉西他滨超液化碘油乳剂治疗晚期肝肿瘤的可行性及毒副反应。方法: 31例肝晚期肿瘤,用吉西他滨超液化碘油乳剂栓塞治疗,部分直接灌注化疗,首次治疗后初步评估早期疗效及毒性反应。结果:31例中, 4例肺癌肝转移, 8例胰腺癌肝转移, 7例结肠癌肝转移, 12例巨块型肝癌。首次治疗后,腹痛症状及食欲情况明显好转,而且其毒副作用不明显。结论:吉西他滨超液化碘油乳剂栓塞、灌注治疗肝肿瘤,是安全的,而且能改善病人的生活质量,并且未见不可耐受副反应。Purpose:To investigate the feasibility of Gemci tabine with Lipiodol Emulsion for treatment of advanced liver cancer and its si de-effects.Methods:31 advanced liver cancer cases were treated with Gemcit abine with Lipiodol Emulsion for arterial embolijation some were treated with ar terial infusion chemotherapy.Early therapeutic effect and side-effects were eva luated after the first initial therapy. Results:In 31 patients ,4 patients were liver metastases from l ung carcinoma,8 patients were liver metastases from pancreatic carcinoma ,7 pati ents were liver metastases from colorectal carcinoma,12 patients were primary ma ssive liver cancer After the first treatment,the symptoms of gastrc pain and app etite were ameliorated,more over,the side-effects (omit,heart toxicity ,myelosu ppression) was slight. Conclusions:treatment using gemcitabine with lipiodol emulsion for arterial emboliyation and arterial infusion for chemtherapy in advanced live r cancer is not only safe but also improves the patients' quality of life.The r esults suggested that the treatment is mild in toxicity.

关 键 词：吉西他滨 超液化碘油 乳剂 肝肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]