62例肺大细胞癌临床特点及治疗结果  

Clinical characteristics and treatment results of large cell lung cancer--62 case report

作　　者：陈东福[1] 欧广飞[1] 程贵余[1] 周宗玫[1] 赵路军[1] 王绿化[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院放射治疗科,北京100021

出　　处：《中华放射肿瘤学杂志》2004年第4期282-284,共3页Chinese Journal of Radiation Oncology

摘　　要：目的　分析肺大细胞癌的临床特点及预后。方法　 6 2例均有病理学诊断。Ⅰ期 5例 ,Ⅱ期 13例 ,Ⅲ期 30例 ,Ⅳ期 14例。手术切除 4 5例 (根治术 38例 ,姑息切除术 7例 ) ,非手术治疗 17例(单纯放射治疗 11例 ,单纯化疗 4例 ,放射治疗 +化疗 2例 )。术后放射治疗包括纵隔和同侧肺门 ,总量 4 0～ 6 0Gy ,4～ 6周完成。单纯放射治疗包括原发病灶、纵隔和肺门 ,总量 36～ 70Gy ,4～ 7周完成。结果　全组 1、3、5年生存率和中位生存期分别为 2 5 .7%、15 .4 %、11.6 %和 11.6个月 ;根治术的分别为 5 1.3%、2 4 .7%、2 4 .7%和 13个月 ;姑息手术的分别为 0 %、0 %、0 %和 2个月 ;非手术治疗的分别为4 1.2 %、2 1.2 %、7.0 %和 11个月。结论　肺大细胞癌远地转移率高 ,预后较差 ,手术治疗者长期生存比其他类型肺癌差 。Objective Objective To evaluate the clinical characteristics and treatment results of 60 patients with large cell lung cancer (LCLC). Methods All sixty-two patients were diagnosed histopathologically with 5 in stage I, 13 in stage Ⅱ, 30 in stage Ⅲ and 14 in stage Ⅳ. Forty-five patients received primary surgical resection with 38 radical resection and 7 palliative resection. Non-surgical treatment was given to 17 patients. Mediastinum and ipsilateral hilum were treated to the total dose of 40-60?Gy in 4-6 weeks in 16 patients as postoperative adjuvant radiotherapy. For patients treated by radiation alone, the primary tumor bed, bilateral mediastinum and ipsilateral hilum were treated to the total dose of 36-70?Gy in 4-7weeks. Results The overall 1-、3- and 5-year survival rates were 25.7%, 15.4% and 11.6%, respectively with the median survival time of 11.6 months. In the radically resected patients, the 1-、3- and 5-year survival rates and the median survival time were 51.3%, 24.7%, 24.7% and 13 months, compared to those of 0%, 0%, 0% and 2 months in the palliatively resected group. In non-surgical treatment group, the 1-、3- and 5-year survival rates and the median survival time were 41.2%, 21.2%, 7.0% and 11 months,respectively. Conclusions The prognosis of large cell lung cancer is poor due to high distant metastasis rate. The long-term survival rate after radical resection is worse than the other lung cancers, but similar to the non-surgical treatment.

关 键 词：肺大细胞癌 临床特点 治疗 预后 病理学诊断 

分 类 号：R734.2[医药卫生—肿瘤]