Wernicke-Geschwind语言模型的fMRI初步检验  

Preliminary fMRI explore of the Wernicke-Geschwind model of language

作　　者：赵小虎[1] 王培军[1] 李春波[1] 杨振燕[1] 王金红[1] 胡正辉[2] 毛新清[1] 

机构地区：[1]同济大学附属同济医院影像科,上海200065 [2]浙江大学物理系交叉学科实验室

出　　处：《中国医学影像技术》2004年第12期1836-1838,共3页Chinese Journal of Medical Imaging Technology

基　　金：本课题受国家自然科学基金资助 (30 2 0 0 0 81 )。

摘　　要：目的　利用fMRI方法检验经典的Wernicke Geschwind语言模型。方法　以BlockDesign设计模式 ,对 10名正常中国人的听觉性语言 (词语水平 )功能进行BOLD磁共振脑功能成像 ,并与经典的Wernicke Geschwind语言模型进行比较与检验。结果　所有受试者均完成了实验要求 ,且头动范围小于 1个像素大小。语言任务激活的脑区包括 :双侧颞上回、双侧运动区 (前后运动区及辅助运动区 )、双侧小脑半球及视皮层 ,左侧颞横回、左侧角回 ,右侧颞中回及以及扣带回后部。结论　经典的语言模型存在较明显的不足与缺陷 ,需要进一步完善。Objective To preliminarily testify the classical language model of Wernicke Geschwind with BOLD fMRI. Methods Ten healthy native Chinese underwent blood oxygenation level dependent (BOLD) contrast functional magnetic resonance imaging (fMRI) on a 1.5T system when they were listening actively to emotionally neutral words. Results Compared with classical language model of Wernicke Geschwind,different cortical areas associated with auditory language were found. The activation areas included bilateral superior temporal gyrus,bilateral motor cortex, bilateral cerebellum,bilateral visual cortex and left angular gyrus,left temporal transversal gyrus, right middle temporal gyrus and right posterior cingulum. Conclusion Classical language model of Wernicke Geschwind has some deficits and needs to be improved.

关 键 词：听觉性语言 功能性磁共振成像 Wernicke-Geschwind模型 研究设计 

分 类 号：R445.2[医药卫生—影像医学与核医学] R338.2[医药卫生—诊断学]