不同月龄人App老年痴呆病转基因小鼠行为学观察比较  

Behavioral comparison between different aged h-App transgenic mice with Alzheimer’s disease

作　　者：黄澜[1] 朱华[1] 高虹[1] 张兵林[1] 刘亚莉[1] 秦川[1] 

机构地区：[1]中国医学科学院实验动物研究所,北京100021

出　　处：《中国老年学杂志》2004年第12期1185-1186,共2页Chinese Journal of Gerontology

基　　金：回国人员基金;北京市自然科学基金 (50 32 0 1 4 )

摘　　要：目的　通过跳台和水迷宫实验 ,对不同月龄的App转基因阳性小鼠及转基因阴性小鼠进行观察比较。 方法　采用水迷宫及跳台实验测定小鼠的学习记忆能力。结果　 9月龄App阳性小鼠水迷宫实验中寻找逃避平台的潜伏期较 6月龄阳性小鼠有显著差异 ,1 0、1 1、1 2月龄阳性小鼠较 6月龄阳性小鼠有极其显著差异 (P <0 0 1 )。跳台实验表明 1 2月龄阳性小鼠较 6月龄阳性小鼠有明显差异 (P <0 0 1 )。结论　随着增龄 ,转基因小鼠行为缺陷日见明显。该现象符合老年痴呆病程的发展。Objective To compare the behavioral difference between App transgenic positive mice and negative mice in different age periods. Methods Jump platform experiment and water maze experiment were used. Results In water maze experiment, the latent period of seeking for platform of 9 months old App (+) mice was longer than that of 6 months old App (+) mice, with statistical prominent differentia; 10, 11, 12 months App (+) mice also have a significant difference in statistics with 6 months old App (+) mice. In jump platform experiment, there was a prominent difference of jumping time in statistic between 12 months old App (+) mice and 6 months old App (+). Conclusions Along with ageing, the transgenic mice have apparent defects in behavior, this phenomena accords with the development of Alzheimer’s disease.

关 键 词：阿尔茨海默病 APP转基因 行为学 

分 类 号：R749.16[医药卫生—神经病学与精神病学]