牛乳铁蛋白稳定性研究  

Study on the Stability of Bovine Lactoferrin

作　　者：许宁[1] 姚京忠[1] 徐文斌[1] 

机构地区：[1]浙江省衢州市人民医院药剂科,衢州市324000

出　　处：《中国药房》2005年第3期215-216,共2页China Pharmacy

摘　　要：目的 :研究牛乳铁蛋白原料的稳定性。方法 :以反相高效液相色谱法测定牛乳铁蛋白及其杂蛋白的含量 ,分别用强光照射法、加速试验法和室温留样观察法对牛乳铁蛋白原料进行稳定性试验。结果 :牛乳铁蛋白检测浓度线性范围为25～1000μg/ml,RSD=0 .05 % ;其在强光照射、加速试验和室温留样观察试验中 ,各项指标均符合质量标准。结论 :牛乳铁蛋白在室温、密闭的贮存条件下性质稳定。OBJECTIVE:To study the stability of Bovine Lactoferrin.METHODS:The content of Bovine Lactoferrin and its hybridprotein were determined by RP-HPLC.The stability of the samples was tested by high-light exposure,accelerating experiment and room temperature storage observation method.RESULTS:The linear range for Bovine Lactoferrin was25～ 1000μg/ml,RSD=0.05%.Under the high-light exposure experiment,accelerating experiment and room temperature storage observation,all the criteria were found to be in line with the quality standard specification.CONCLUSION:Stored under room temperature and airtight condition,Bovine Lactoferrin is stable in quality.

关 键 词：牛乳铁蛋白 杂蛋白 含量 反相高效液相色谱法 稳定性 

分 类 号：R927.11[医药卫生—药学]