大白鼠内毒素休克的代谢变化及山莨菪碱(654-2)对其的影响  

Changes of Metabolism and Protective Effects of Anisodamine (654-2) in Endotoxic Shock of Rat

作　　者：甘继宏[1] 郭炯[2] 

机构地区：[1]兰州军区乌鲁木齐总医院 [2]新疆医学院基础部病理生理学教研室

出　　处：《新疆医学院学报》1993年第2期71-75,共5页

摘　　要：用E.Coli内毒素复制休克模型。将内毒素注入静脉后立即引起ABP先降、后升、再降的双向反应。在ABP第二次降至<8.0 kPa时,迅速采血样检查,结果为:血气无异常(P>0.05),血液pH降低(p<0.001);动脉血中葡萄糖水平降低(P<0.001),乳酸和NPN升高(P<0.01,P<0.05),胰岛素水平无明显变化(P>0.05)。预先应用654-2后再进行同样实验,发现:PaO_2-PrO_2差出现代偿性增大(p<0.05),乳酸回降至正常水平,pH显著回升(P<0.05),低血糖症明显改善(P<0.05),只是对高氮质血症无影响(P>0.05)。再将休克和654-2+休克2组的ABP作动态对比观察,未见654-2对ABP有任何影响。单纯休克的血糖水平随ABP而进行性降低;在ABP2次下降前,即注内毒素后30 min再静脉注入肾上腺素,血糖仍有升高反应,在观察期内一直在正常水平之上。作者结合实验结果对发病过程作了分析。The shock was reproduced by injection of inactive E. Coli endotoxin intra-venous in rat. There were two phases in reaction of ABP after administration of endotoxin immediately, when the ABP fell to<8.0 kPa, second the arterial and central venous blood example were drawn to analyze, the results were as follows: the blood gases, PaO_2-PvO_2 difference and the level of insulin in plasma didn't changed significantly, the concentration of lactate and NPN in plasma increased (P<0.001), the blcod pH deereased (P<0.001). After the rat pretrcated with 654-2 the hyperiactacidemia disappeared the hypoglycemia improved significantly (P<0.05), the blood pH rose baekward near to control but still was abnormal (P<0.05), only the hyper-nitremia didn't changed. In endotoxic shock,ABP decreased progressively which was not influenced by pre-treated with 654-2, the blood sugar decreased continually, that was in keeping synchronization with ABP falling; when the rat received epinephrine iv. at 30 minute after injection of endotoxin,the plasma glucose increased instead of hypoglycemia, In this paper the pathogenesis of shock was discussed.

关 键 词：内毒素 休克 胰岛素 山莨菪碱 

分 类 号：R364.14[医药卫生—病理学]