Ⅲa期非小细胞肺癌术后放疗加化疗的疗效分析  

Therapeutic Analysis of Postoperative Radiochemotherapy for Stage Ⅲa None-small Cell Lung Cancer

作　　者：李昉[1] 彭瑛[1] 韦小梅[1] 徐珂[1] 颜高姝[1] 王冀川[1] 王捷[1] 

机构地区：[1]四川省肿瘤医院放疗科,四川成都610041

出　　处：《四川肿瘤防治》2005年第1期18-20,共3页Sichuan Journal of Cancer Control

摘　　要：目的 :探讨Ⅲa期非小细胞肺癌 (NSCLC)患者术后放疗加化疗的临床意义。方法 :回顾性分析 10 2例Ⅲa期NSCLC患者术后放疗与单纯手术治疗的生存率及复发情况。其中术后放疗加化疗 76例 ,单纯手术 2 6例。结果 :术后放化疗组和单纯手术组 5年的生存率分别为 32 . 2 %和 9 1% ,两组比较有显著性差异 (P <0 . 0 5 )。术后放化疗组的 5年局控率为 73 .7% (5 6 / 76 ) ,明显高于单纯手术组的 5 3 .8% (14 / 2 6 ) ,P <0 . 0 5。术后 5年远处转移率放化疗组为 5 0 .0 % (38/ 76 ) ,单纯手术组为 6 1 5 % (16 / 2 6 ) ,两组比较无显著性差异 (P >0 . 0 5 )。结论 :本组资料提示 ,对Ⅲa期非小细胞肺癌术后患者行放疗加化疗 ,可以提高生存率 ,且治疗方式、N分期、血红蛋白为生存率的独立预后因素。Objective:To evaluate the results of postoperative radiochemotherapy for stage Ⅲa non-small cell lung cancer(NSCLC).Methods:One hundred and two patients with stage Ⅲa NSCLC were divided into two groups:76 cases received postoperative radiochemotherapy were in group A,26 cases received surgical treament alone were in guoup B.The clinical data of two groups were analyzed retrospectively.Results:In group A and in group B the overall 5-year survival rates were 32.2% and 9.1% respectively(P<0.05),the local control rates were 73.7%(56/76)and 53.8%(14/26) respectively(P<0.05) and the metastasis rates were 50.0%(38/76)and 61.5%(16/26) respectively(P>0.05).Between two groups,there were significant difference in overall 5-year survival rates and local control rates.Conclusion:Postoperative radiochemotherapy can improve the survival rate for patients with stage Ⅲa NSCLC.Multivariate analysis showed that therapeutic modality,N staging and hemoglobin are the independent prognostic factors.

关 键 词：非小细胞肺癌 手术治疗 放疗 化疗 生存率 Ⅲa期 NSCLC 肿瘤 

分 类 号：R734.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]