^(18)F-FDG符合线路显像在不明原发灶肿瘤中的临床价值  

The clinical value of ^(18)F-FDG coincidence SPECT in unknown primary tumors

作　　者：付占立[1] 林景辉[1] 张春丽[1] 范岩[1] 胡怀湘[1] 王荣福[1] 

机构地区：[1]北京大学第一医院核医学科,100034

出　　处：《中华核医学杂志》2004年第6期328-329,共2页Chinese Journal of Nuclear Medicine

摘　　要：目的　评价1 8F 脱氧葡萄糖 (FDG)符合线路显像在不明原发灶肿瘤 (UPT)中的临床价值。方法　UPT患者 36例 ,在1 8F FDG符合线路显像后 4周内进行常规影像学检查。结果　1 8F FDG符合线路显像对原发灶的检出灵敏度为 4 2 % (15 36例 ) ;1例原发灶仅被1 8F FDG显像发现 ,3例首先被1 8F FDG显像发现 ,后在1 8F FDG显像结果的提示下被其他影像学检查发现 ,11例同时分别被1 8F FDG显像和常规影像学检查发现 ;14 % (5 36例 )患者因找到原发灶而改变了治疗方案 ;5 3% (19 36例 )患者发现新的转移灶。结论　1 8F FDG符合线路显像是寻找UPT原发灶的一种有效方法 ,并可同时评价患者的全身转移情况 ,可为选择最佳治疗方案和预后评价提供依据。Objective To assess the value of 18F-fluorodeoxyglucose (FDG) coincidence SPECT in unknown primary tumors (UPT). Methods A retrospective analysis of 36 patients referred to 18F-FDG coincidence SPECT imaging for metastases from UPT was performed. Metastases were located in bone (n=19), lymph node (n=11), pleura (n=4) and liver (n=2). All of the 36 patients took conventional imaging diagnostic work-up within 4 weeks after 18F-FDG coincidence SPECT. Results Fifteen (42%) primary tumors were found by 18F-FDG coincidence SPECT and were verified by histopathology (n=6) or conventional imaging procedures and clinical follow-up (n=9). The sensitivity of 18F-FDG coincidence SPECT for detecting primary tumors was 42% (15/36). Among the 15 primary tumors identified by 18F-FDG coincidence SPECT, one was only detected by 18F-FDG; three were detected first by 18F-FDG, and then by conventional imaging methods, by oriented imaging; eleven were found by both 18F-FDG and conventional imaging modalities separately. 18F-FDG coincidence SPECT findings affected the therapeutic protocols of 14% (5/36) patients. 18F-FDG coincidence SPECT also identified additional previously unknown metastases in 53% (19/36) patients. Conclusion 18F-FDG coincidence SPECT is an effective method for primary tumor detection and for evaluation of tumor burden in UPT patients, and it is helpful for staging, selecting appropriate treatment protocols and predicting prognosis for these patients.

关 键 词：^18F-FDG 肿瘤 不明原发灶 符合线路 患者 临床价值 影像学检查 时评 发现 结论 

分 类 号：R730.4[医药卫生—肿瘤]