77例农村帕金森病患者的家族史及其他影响因素  

Family History, Psychosocial Factors of Parkinson's Disease--a Case-control Study in Linxian County

作　　者：马莉[1] 高晓虹[1] 陈汶[2] 张翠丽[1] 王研[1] 周莉[1] 宋煜青[3] 周东丰[3] 乔友林[2] 

机构地区：[1]大连医科大学流行病学教研室 [2]中国医学科学院/中国协和医科大学肿瘤医院/肿瘤研究所流行病室 [3]北京大学精神卫生研究所

出　　处：《中国心理卫生杂志》2005年第2期71-72,共2页Chinese Mental Health Journal

摘　　要：目的:探讨家族史、心理社会因素等与帕金森病的关系。方法:采用1:2配对的病例对照方法,分析家族史、心理社会因素、疾病史等对帕金森病的影响。使用条件Logistic回归模型统计筛选危险因素,建立多变量回归模型。结果:家族史(OR=13.54)、重大精神创伤(OR=3.02)、人际交往状况(OR=2.10)可增加帕金森病的风险。结论:本研究支持家族史及心理社会因素等在帕金森病病因中的作用。Objective:To investigate the relationship of family history , psychosocial factors of PD (Parkinson's Disease) in a rural population in north China. Methods: A case control study was conducted in rural population in China. Cases (n=77) have been diagnosed by a two-phase screening by neurologists and interviewers in May, 2000. Controls (n=154), randomly selected from the same cohort, who were matched with patients (control/cases ra-tio=2) for sex, age (±5 years). Information of participants' characteristics came from the interview in 2001. Data was analyzed by using conditional logistic regression by SAS 6.12. Results: Family history (OR=13.54) .negative life events (OR=3.02), interpersonal communication (OR=2.10) were associated with a significantly elevated risk for the onset of PD. Conclusion: These results indicate that family history, psychosocial factors were risk factors of PD.

关 键 词：农村 帕金森病 家族史 影响因素 多变量回归模型 病因 

分 类 号：R742.5[医药卫生—神经病学与精神病学]