1-乙基-6-氟-1,4-二氢-4-氧代-7-(4-芳酰硫代氨甲酰基-1-哌嗪基)-3-喹啉羧酸的合成及抗菌作用  

SYNTHESIS AND ANTIBACTERIAL ACTION OF 1-ETHYL-6-FLUORO-1, 4-DIHYDRO- 4-OXO-7-(4-AROYLTHIOCARBAMOYL-1 -PIPERAZINYL)- 3-QUINOLINE CARBOXYLIC ACIDS

作　　者：贾学顺[1] 王玉炉[1] 何方淑[2] 单英芳[2] 李用芳[2] 王昀[3] 

机构地区：[1]河南师范大学化学系,新乡453002 [2]河南师范大学生物系,新乡453002 [3]同济医科大学医学系

出　　处：《药学学报》1993年第6期477-480,共4页Acta Pharmaceutica Sinica

基　　金：河南省科委自然科学基金

摘　　要：1-乙基-6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-3-喹啉羧酸(氟哌酸,norfloxacin),因有抗菌谱广、抗菌活性强等优点而引起人们广泛的兴趣,但尚有排泄快、生物利用度低等缺点。Thirteen new 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-aroyl-thiocarbamoyl- 1 piperazinyl)-3-quinoline carboxylic acids were prepared, Their structures were characterized by elemental analysis, IR, HNMR and MS spectra.Preliminary pharmacological tests indicated that some of compounds Ia～m possess strong inhibiting activity against Escherichia coli, Bacillus subtilis and Proteus at concentration of 100 μg/ml.

关 键 词：喹啉羧酸 氟哌酸 合成 抗菌作用 

分 类 号：R914.5[医药卫生—药物化学]