海岛轮环藤碱-N-氧化物的制备和结构  

PREPARATION AND STRUCTURAL ELUCIDATION OF INSULARINE-N-OXIDES

作　　者：赖盛[1] 赵同芳[1] 王宪楷[1] 志津里芳一 山村庄亮 

机构地区：[1]华西医科大学药学院,成都610041 [2]庆应义塾大学理工学部

出　　处：《药学学报》1993年第7期557-560,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金

摘　　要：双苄基异喹啉(BBI)生物碱在植物界分布较广,有的有较强生理活性,是一类重要异喹啉化合物。现已从13科51属植物中分得这类生物碱400余种,包括首尾氧桥型45种和尾尾氧桥型360种左右,其中N-氧化物约30种,但首尾氧桥BBI生物碱-N-氧化物迄今仅发现一种。Oxidation of insularine (Ⅰ) with m-chloroperbenzoic acid yielded four insularine-N-oxides. Two of them are identical in every respect with our insularine-2β-N-oxide (Ⅱ) and insularine-2'β-N-oxide (Ⅲ), two rare examples of naturally occurring head-to-tail bisbenzyliso-quinoline N-oxides newly isolated from Cyclea sutchnenensis, which confirmed the structures of the two novel natural N-oxides. The other two are new. compounds and their structures have been established as insularine-2'α-N-oxide (Ⅳ) and insularine-2β-2'β-N, N-dioxide (Ⅴ), on the basis of spectral data (UV, IR. ~1HNMR, NOEDS AND MS) analysis.

关 键 词：海岛轮环藤碱 制备 合成 

分 类 号：R914.5[医药卫生—药物化学]