桂皮酸对NB_4细胞增殖和分化作用的实验研究  

Studies on the Effect of Cinnamic Acid on Proliferation and Differentiation of NB_4 Cells

作　　者：赵国江 陶艳玲[2] 左学兰 张颢[2] 

机构地区：[1]河南息县人民医院,河南息县464300 [2]武汉大学中南医院,武汉430071 [3]河南息县公疗医院,河南息县464300

出　　处：《四川肿瘤防治》2003年第1期7-8,共2页Sichuan Journal of Cancer Control

摘　　要：目的 :探讨桂皮酸对NB4 细胞的增殖和分化的作用。方法 :采用光镜观察形态变化 ,流式细胞术检测CD11b和CD33。结果 :桂皮酸作用NB4 细胞后 ,可使NB4 细胞增殖明显受抑 ,诱导NB4 细胞向终未细胞分化 ;实验组与对照组的分化率差异明显 (P <0 0 1) ;CD11b表达升高 ,CD33表达下降 (P <0 0 5 )。结论 :桂皮酸对NB4Objective: To investigate the effect of cinnamic acid(CINN) on proliferation and differentiation of NB 4 cells.Methods:The morphology and the proliferation rates of NB 4 cells were studied by microscope,CD 33,CD 11 antigens were analysed by flow cytometry.Results:Treated with cinnamic acid,NB 4 Cells exhibited a characteristics in cell differentiation,and their proliferation was significantly inhibited.After CINN treatment,the expression of CD 33 was decreased,but the expression of CD 11b was increased(P<0 05).Conclusion:CINN could inhibite the proliferation of NB 4 cells,and had the inducing differentiation effect on NB 4 Cells.

关 键 词：NB4细胞 桂皮酸 增殖 细胞分化 作用 实验研究 CD11B 光镜观察 形态变化 诱导分化 

分 类 号：R73-36[医药卫生—肿瘤]