鼻NK/T细胞淋巴瘤瘤细胞分化状态的探讨  

Study on the status of cell differentiation in nasal NK/T-cell lymphomas

作　　者：姜余梅[1] 刘卫平[1] 唐琼兰[1] 李甘地[1] 郭嘉[1] 廖殿英[1] 

机构地区：[1]四川大学华西医院病理科,成都610041

出　　处：《中华病理学杂志》2003年第5期437-439,共3页Chinese Journal of Pathology

基　　金：四川省科技厅重点课题资助项目( 0 1SG 0 1 3 0 3);纽约中华医学基金部分资助(CMB 0 0 72 2 )

摘　　要：目的　探讨鼻自然杀伤 (NK) /T细胞淋巴瘤肿瘤细胞的分化状态。方法　收集已确诊的 88例鼻NK /T细胞淋巴瘤的临床资料。免疫组织化学染色选用的抗体有 :T细胞分化抗原(CD3ε、CD5、CD1a)、NK细胞相关抗原 (CD56、CD57) ,还有CD3 4和CD3 8抗原。结果　 (1)病变部位以鼻腔最常见 ,其次为咽部 ,主要体征为溃疡或黏膜糜烂。本组 88例鼻NK/T细胞淋巴瘤中有 62例(70 5% )之瘤细胞呈弥漫性增生和浸润 ,瘤细胞中等大小者有 71例 (80 7% ) ;(2 ) 88例NK /T细胞淋巴瘤中 ,T细胞标记CD3ε阳性者 78例 (88 6% ) ,CD5阳性者 56例 (63 6% ) ,NK细胞标记CD56阳性者 2 5例 (2 8 4% ) ;CD57、CD1a、CD3 4和CD3 8均为阴性。结论　鼻NK/T细胞淋巴瘤瘤细胞的分化可能已超越前体细胞阶段 。Objective To evaluate the status of cell differentiation in nasal NK/T cell lymphomas. Methods The clinical data of 88 cases of NK/T cell lymphomas were collected. Antibodies to the following antigens were used in the immunohistochemical study: T cell differentiation antigens (CD3ε, CD5 and CD1a); NK cell associated antigens (CD56, CD57) and antibodies of CD34 and CD38. Results (1) Clinicopathology: clinically, frequently involved sites were the nasal cavity and the pharynx. Ulceration and erosion of the mucosa were common signs. Pathologically, diffuse infiltration of the tumor cells was observed in 68 of 88 (70.45%) cases of nasal NK/T cell lymphomas. In 71 (80.68%) cases infiltrated cells were predominantly medium to large sized; (2) Differentiation status of tumor cells: the tumor cells expressed CD3ε in 78/88 (88.64%); CD5 in 56/88 (63.63%), CD5 6 in 25/88 (28.41%) and no positivity for CD1a, CD57, CD34 and CD38. Conclusion Status of tumor cell differentiation in nasal NK/T cell lymphoma may have passed the stage of progenitor cell differentiation but not yet to the stage of mature T or NK cells.

关 键 词：瘤细胞 鼻NK/T细胞淋巴瘤 阳性 NK细胞 CD38 CD1A CD56 中等 结论 阶段 

分 类 号：R739.62[医药卫生—肿瘤]