小剂量阿司匹林诱发上消化道出血的临床分析  

Clinical analysis of upper gastrointestinal bleeding induced by low-dose aspirin

作　　者：殷健[1] 吴志强[1] 候鹏[1] 

机构地区：[1]解放军304医院,北京100037

出　　处：《药物不良反应杂志》2005年第1期17-20,共4页Adverse Drug Reactions Journal

摘　　要：目的:总结口服小剂量阿司匹林(Aspirin,ASP)诱发上消化道出血的临床特点及防治对策。方法:调查同期非食道静脉曲张性上消化道出血患者380例(402例次),根据出血前是否正在服用ASP分为两组:ASP组38例(出血42例次)与非ASP组342例(出血364例次),回顾性分析两组间的临床特点。结果:ASP组上消化道出血患者,平均年龄(64.5±5.4)岁,高于非ASP组(43.5±16.5岁),胃溃疡和胃黏膜病变的发生比例(69.1%)高于非ASP组(26.70%)(P<0.01),57.1%的患者出血前有诱因。出血量、Hb两组间无差异,止血时间(平均3.7d)长于非ASP组(平均2.3d)(P<0.05)。结论:口服小剂量ASP是老年患者上消化道出血的主要原因之一,其中胃部病变发生比率较高,止血所需时间较长,口服ASP时加强胃粘膜的保护、控制诱因有望预防上消化道出血的发生。Objective: To investigate the clinical characteristics and treatment of the upper gastrointestinal (GI)bleeding induced by low-dose aspirin (ASP). Methods: The data of patients with bleeding from non-esophageal varices were retrospectively analysed and divided into ASP group(38 cases) and non-ASP group(342)according to ASP administration before bleeding. Results: Average age of ASP group(64.5±5.4)is older than non-ASP group (43.5±16.5). The occurrences of gastric ulcer and mucosal lesion were higher in ASP group(69.1%)than in non-ASP group(26.70%)(P<0.01).No difference was found in bleeding amount and Hb .Hemostatic time was longer in ASP group(average 3.7 days)than in non-ASP group(average 2.3days)(P<0.05). Conclusion: Low-dose ASP is attributed to upper GI bleeding in old patients-with high occurrence of gastic disorders and longer hemostatic time.

关 键 词：阿司匹林 副作用 上消化道出血 

分 类 号：R573.2[医药卫生—消化系统]