伽玛刀治疗68例肺部原发恶性肿瘤效果分析  

To analyze the effect of the primary lung malignant tumor after gamma knife radiotherapy of 68 cases

作　　者：宋宇[1] 李天然[1] 陈忠华[1] 郑春雨[1] 李铭山[1] 

机构地区：[1]南京军区福州总医院医学影像科,350025

出　　处：《福建医药杂志》2005年第1期14-16,共3页Fujian Medical Journal

摘　　要：目的探讨肺癌不同病理类型伽玛刀疗效的评价与评价方法选择.材料与方法收集68例可以准确测量肿块直径的肺内肿块进行治疗前后的比较.68例肺癌中,鳞癌32例,腺癌12例,小细胞癌18例,大细胞癌6例;两肺共有病灶81个,肿块直径大小为0.8～13.5 cm.结果68例中,完全缓解率(CR)14例占20.6%;部分缓解率(PR)43例占63.2%;无变化(NC)3例占4.4%;进展(PD)8例占11.8%;CR+PR占83.8%.其中鳞癌、腺癌及小细胞癌CR+PR均大于80%,大细胞癌CR+PR为50%.结论伽玛刀治疗对肺癌病灶的控制有显著的效果,鳞癌、腺癌及小细胞癌的伽玛刀治疗效果相似,大细胞癌的放疗效果稍差.影像手段评价肿瘤有一定的局限性,PET将成为最佳的影像评价手段.Objective To investigate the radiotherapy effect of the different pathologic type in lung cancer after gamma knife treatment and evaluate the choice of the methods.Material and methods To collect 68 cases that lumps inside lung can be accurately measure and compare pre-radiotherapy to post-radiotherapy.Thirty-two cases were squamous carcinoma,and 12 cases adenocarcinoma,and 18 cases small cell carcinoma and six cases big cell carcinoma in the 68 case.There are 81 focus in two lungs.The diameter of lumps are 0.8-13.5 cm.Result The complete reponse(CR)rate,parital response(PR)rate,no change(NC)rate and progression disease(PD)rate were 20.6%(14/68),63.2%(43/68),4.4%(3/68),11.8%(8/68).CR+PR is 83.8%.The CR+PR of squamous carcinoma,adenocarcinoma,and small cell carcinoma were above 80%,while it was 50% of big cell carcinoma.Conclusion There are notable effect to control the focus of lung cancer after the Gamma knife treatment.The effect of post-radiotherapy were similar among squamous carcinoma,and adenocarcinoma small cell carcinoma,but big cell carcinoma's effect was poorer than other pathologic type.It has some limit that evaluate the effect of Gamme knife to utilize image,and the PET will become the best image in the evaluation of radiotherapy.

关 键 词：伽玛刀治疗 PR 小细胞癌 大细胞癌 鳞癌 肺癌 腺癌 评价手段 结论 收集 

分 类 号：R734.2[医药卫生—肿瘤]