乳腺癌中激素受体和雌激素调节蛋白PS_2的表达及其与预后的关系  

Relationship between the Expression of Hormone Receptor, PS _ 2 and Prognosis in Patients with Breast Cancer

作　　者：杨秀萍[1] 郑丽端[1] 郭涛[1] 邵俊[1] 贺骏[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院病理科,武汉430022

出　　处：《华中科技大学学报（医学版）》2005年第1期108-110,共3页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

摘　　要：目的探讨乳腺癌中雌激素受体(ER)、孕激素受体(PR)和雌激素调节蛋白(PS2)的表达及其与预后的关系.方法应用免疫组织化学链霉亲和素-生物素过氧化物酶连接法(SABC法)检测ER、PR和PS2在76例随访5～9年的乳腺浸润性癌中的表达.结果 ER、PR和PS2三者的表达两两之间呈明显正相关(P<0.01),与患者的年龄关系密切(P<0.01),而与肿瘤大小、腋窝淋巴结有无转移、组织学分类以及分级无明显相关.在预后方面,PR和PS2的表达与患者的无瘤生存、复发及死亡状况密切相关(均P<0.05).结论 PR和PS2能够反映雌激素调节系统的功能和完整性,作为评估预后的指标优于ER.同时进行ER、PR和PS2的三联检测,可以得到3个指标的累积效果,以弥补单一ER检测或ER、PR检测的不足.Objective To explore the protein expression of estrogen receptor (ER), progesterone receptor (PR) and presenilin 2 (PS 2) in breast cancer and the relation with prognosis of patients. Methods The expression of ER, PR and PS 2 was detected by immunohistochemistry SABC staining in 76 cases of invasive breast cancer, which had been followed up for 5-9 years. Results There was significantly positive correlations among the expression of ER, PR and PS 2 (P<0.01). All of the three above proteins had a close correlation with the patients’age (P<0.01) as well, but no significant correlation between the expression of ER, PR, PS 2 and tumor size, metastasis of axillary’s lymph node, histological classification and grade. There was a close correlation between the expression of PR and PS 2 and the tumor-free survival, recurrence and overall survival (P<0.05). Conclusion PR and PS 2 could indicate the function and completeness of the regulation system of estrogen, while they were better than ER as markers for evaluating prognosis. The calculating effect of these indicators would be obtained by detecting ER, PR and PS 2 at the same time. It would be better than just testing ER or ER and PR to prognosticate the patients’ response to hormonal treatment.

关 键 词：PR ER 表达 预后 PS2 雌激素调节蛋白 乳腺癌 SABC法 累积 过氧化物酶 

分 类 号：R737[医药卫生—肿瘤] R735[医药卫生—临床医学]