Synthesis of a Novel Series of S-Alkyl Thiobenzoate Compounds as Farnesyltransferase Inhibitors  

作　　者：ShengBiaoWAN JunFENG FengMingCHU ZongRuGUO 

机构地区：[1]DepartmentofMedicinalChemistry,InstituteofMateriaMedica,ChineseAcademyofMedicalSciences＆PekingUnionMedicalCollege,Beijing100050

出　　处：《Chinese Chemical Letters》2005年第2期151-154,共4页中国化学快报（英文版）

基　　金：This work was supported by National Basic Research Program(973 Program:G1998051102).

摘　　要：S-akyl thiobenzoate compounds were designed as farnesyltransferase (FTase) inhibitors.An effective synthetic method was explored. The structures of the target compounds wereelucidated by NMR spectral and elemental analysis.

关 键 词：S-Akyl thiobenzoate compounds BENZODIAZEPINE farnesyltransferase. 

分 类 号：O625.6[理学—有机化学] R971.2[理学—化学]