BENZODIAZEPINE

作品数:42被引量:26H指数:3
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相关领域:医药卫生更多>>
相关作者:秦珅李庆云蒋为群王彦林莹妮更多>>
相关机构:台湾大学兰斯大学上海交通大学医学院附属瑞金医院河北师范大学更多>>
相关期刊:《Journal of Pharmaceutical Analysis》《Advances in Bioscience and Biotechnology》《Journal of Behavioral and Brain Science》《Journal of Biosciences and Medicines》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划更多>>
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Remimazolam in intensive care unit:Potential applications and considerations
《World Journal of Critical Care Medicine》2024年第3期25-31,共7页Praveen Reddy Elmati Teja Nagaradona Gowthami Sai Kogilathota Jagirdhar Salim Surani 
This manuscript explores the potential use of Remimazolam in the intensive care unit(ICU)and critical care units,considering its pharmacological characteristics,clinical applications,advantages,and comparative effecti...
关键词:Remimazolam Intensive care Critical care ANESTHESIA SEDATION Mechanical ventilation BENZODIAZEPINE 
Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods被引量:1
《Journal of Pharmaceutical Analysis》2023年第5期442-462,共21页Yi-Xin Zhang Yuan Zhang Yu Bian Ya-jie Liu Ai Ren Yu Zhou Du Shi Xue-Song Feng 
supported by the Scientific Research Project of the Department of Education of Liaoning Province,China(Grant No.:ZF2019036).
Benzodiazepines(BDZs)are used in clinics for anxiolysis,anticonvulsants,sedative hypnosis,and muscle relaxation.They have high consumptions worldwide because of their easy availability and potential addiction.They are...
关键词:BENZODIAZEPINE Biological matrices Detectionmethods Samplepreparation 
Pilot Studies on the Novel Hypothesis that TSPO (Peripheral Benzodiazepine Receptor) Is Involved in Benzodiazepine/“Z-Drug” Physical Dependence and/or Withdrawal
《Pharmacology & Pharmacy》2023年第3期72-83,共12页Cheyenne Moffett Katherine J. Kost Austen Thompson Joseph V. Pergolizzi Jr. Tally M. Largent-Milnes Robert B. Raffa Todd Vanderah 
Benzodiazepines and other benzodiazepine receptor agonists, such as the “Z” drugs, are widely prescribed medications mainly used for treating anxiety and seizures, and for inducing sedation. Unfortunately, despite t...
关键词:BENZODIAZEPINE TSPO Rats In Vivo Tests Western-Blot Analysis 
Phenobarbital in the treatment of alcohol withdrawal syndrome
《Journal of Translational Neuroscience》2022年第4期7-11,共5页Tiankai Jiang Lan Jiang Yinhang Li Yuhang Liang Tiantian Jiang Hongyan Liu 
Kunming Health Personnel Training Project[2020-SW(hou bei)-125];Health Research of Kunming City Health Commission Project(2021-03-09-001).
Alcohol withdrawal syndrome(AWS)is a serious disorder affecting alcohol-dependent patients who abruptly stop or reduce their drinking.Mild or moderate AWS usually appears within 6 to 24 h after the last drink,and symp...
关键词:alcohol withdrawal syndrome(AWS) benzodiazepine(BDZ) phenobarbital(PB) 
Research progress on benzodiazepines to treat alcohol withdrawal syndrome
《Journal of Translational Neuroscience》2022年第4期12-16,共5页Tiankai Jiang Yuhang Liang Lan Jiang Yinhang Li Tiantian Jiang Ye Ruan 
Alcohol withdrawal syndrome(AWS)refers to a series of symptoms and signs that chronic al-coholics experience when they suddenly stop drinking or reduce their drinking,usually 12 to 24 h later.These in-clude tremors,fa...
关键词:alcohol withdrawal syndrome(AWS) benzodiazepine(BDZ) symptom-triggered regimens 
Optimisation of Benzodiazepine Immunoassay Using <i>β</i>-Glucuronidase Enzymatic Hydrolysis: A Comparison of Five Different <i>β</i>-Glucuronidase Enzymes
《Journal of Biosciences and Medicines》2022年第1期7-15,共9页Ashraf Mina Leah McNeice Shanmugam Banukumar Santiago Vazquez 
Background: Hydrolysis improves the sensitivity of drug detection for drug classes such as opiates/opioids and benzodiazepines, which are highly metabolized by glucuronidation and sulfation and should...
关键词:β-Glucuronidase Enzyme CEDIA BENZODIAZEPINE 7-Amino Clonazepam 7-Amino Clonazepam 
Flumazenil-insensitive benzodiazepine effects in vitro and in vivo
《中国药理学与毒理学杂志》2021年第9期692-693,共2页WANG Na LIAN Jing-jing CAO Yan-qing YU Gang SU Rui-bin 
Institutional funding from Beijing Institute of Pharmacology and Toxicology。
OBJECTIVE To identify benzodi⁃azepine(BZD)effects that are insensitive to the classical BZD binding site antagonist,flumazenil.Whether the flumazenil-insensitive BZD effects have selectivity on different GABAA recepto...
关键词:GABAA receptor BENZODIAZEPINE non-classical binding sites FLUMAZENIL 
Design,Synthesis and Biological Evaluation of Pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione Derivatives as Novel Neuroprotective Agents
《Chemical Research in Chinese Universities》2021年第3期647-654,共8页QUAN Jishun ZHANG Dongping ZHANG Zhuo WANG Jian MA Chao CHENG Maosheng 
This work was supported by the National Natural Science Foundation of China(No.21977074);the Science and Technology Projects from the Educational Department of Liaoning Province,China(No.2019LQN02).
A series of pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione derivatives was designed and synthesized,and their neuroprotective activity against SH-SY5Y cell injury induced by N-methyl-D-aspartic acid(NMDA)was evaluated.A...
关键词:Neuroprotective activity Ca^(2+)influx Western blotting NR2B-NMDA receptor Molecular docking 
Test of the Popular Benzodiazepine Alprazolam in a Positive Conditioned Place-Preference Model in Female Rats
《Pharmacology & Pharmacy》2021年第5期100-108,共9页Cheyenne Moffett Katherine J. Kost Austen Thompson Michael H. Ossipov Joseph V. Pergolizzi Jr. Sumiyo Umeda-Raffa Robert B. Raffa Tally M. Largent-Milnes Todd Vanderah 
The benzodiazepines were introduced into medical practice during the 1960s. At the time, they represented a safer alternative to extant therapies used...
关键词:BENZODIAZEPINE Conditioned Placepreference ALPRAZOLAM Female Rats 
Association between homicide injury severity and benzodiazepine influence
《Forensic Sciences Research》2021年第1期53-58,共6页Fredrik Tamsen Joakim Sturup Ingemar Thiblin 
The study was financially supported by the Swedish National Board of Forensic Medicine.
There are case reports of offenders inflicting excessive injuries on their victims when under the influence of benzodiazepines.However,the potential association between benzodiazepine influence on the offender and vic...
关键词:Forensic sciences forensic pathology HOMICIDE injury severity injury severity score quantification BENZODIAZEPINES 
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