Remimazolam in intensive care unit:Potential applications and considerations  

作　　者：Praveen Reddy Elmati Teja Nagaradona Gowthami Sai Kogilathota Jagirdhar Salim Surani 

机构地区：[1]Department of Anesthesiology,Saint Clair Hospital,Dover,NJ 07801,United States [2]School of Medicine,St George University,Granada SW170BD,West Indies [3]Department of Medicine,Saint Michaels Medical Center,Newark,NJ 07107,United States [4]Department of Medicine&Pharmacology,Texas A&M University,College Station,TX 77843,United States

出　　处：《World Journal of Critical Care Medicine》2024年第3期25-31,共7页世界重症医学杂志

摘　　要：This manuscript explores the potential use of Remimazolam in the intensive care unit(ICU)and critical care units,considering its pharmacological characteristics,clinical applications,advantages,and comparative effectiveness over current sedatives and anesthetics.We reviewed existing PubMed and Google Scholar literature to find relevant studies on Remimazolam in ICU.We created search criteria using a combination of free text words,including Remimazolam,critical care,intensive care,sedation,anesthesia,pharmacokinetics,and pharmacodynamics.Relevant articles published in the English language were analyzed and incorporated.Remimazolam is an ultra-short-acting benzodiazepine derivative promising for sedation and anesthesia.It is a safer option for hemodynamically unstable,elderly,or liver or kidney issues.It also has comparable deep sedation properties to propofol in the ICU.Furthermore,it reduces post-procedural delirium and patient comfort and reduces the need for additional sedatives in pediatric patients.In conclusion,Remimazolam is an excellent alternative to current sedatives and anesthetics in the ICU.Its cost is comparable to that of current medications.Further research on its long-term safety in the ICU and its broader application and incorporation into routine use is necessary.

关 键 词：Remimazolam Intensive care Critical care ANESTHESIA SEDATION Mechanical ventilation BENZODIAZEPINE 

分 类 号：R47[医药卫生—护理学]