Test of the Popular Benzodiazepine Alprazolam in a Positive Conditioned Place-Preference Model in Female Rats  

作　　者：Cheyenne Moffett Katherine J. Kost Austen Thompson Michael H. Ossipov Joseph V. Pergolizzi Jr. Sumiyo Umeda-Raffa Robert B. Raffa Tally M. Largent-Milnes Todd Vanderah Cheyenne Moffett;Katherine J. Kost;Austen Thompson;Michael H. Ossipov;Joseph V. Pergolizzi Jr.;Sumiyo Umeda-Raffa;Robert B. Raffa;Tally M. Largent-Milnes;Todd Vanderah(Department of Pharmacology, and Comprehensive Pain and Addiction Center, University of Arizona, Tucson, AZ, USA;NEMA Inc., Naples, FL, USA;Neumentum Inc., Morristown, NJ, USA;Enalare Therapeutics, Naples, FL, USA;Pharmaceutical Sciences (Form. Faculty), Hokkaido University of Science, Hokkaido, Japan;School of Pharmacy (Prof Em.), Temple University, Philadelphia, PA, USA;College of Pharmacy (Adjunct), University of Arizona, Tucson, AZ, USA)

机构地区：[1]Department of Pharmacology, and Comprehensive Pain and Addiction Center, University of Arizona, Tucson, AZ, USA [2]NEMA Inc., Naples, FL, USA [3]Neumentum Inc., Morristown, NJ, USA [4]Enalare Therapeutics, Naples, FL, USA [5]Pharmaceutical Sciences (Form. Faculty), Hokkaido University of Science, Hokkaido, Japan [6]School of Pharmacy (Prof Em.), Temple University, Philadelphia, PA, USA [7]College of Pharmacy (Adjunct), University of Arizona, Tucson, AZ, USA

出　　处：《Pharmacology & Pharmacy》2021年第5期100-108,共9页药理与制药（英文）

摘　　要：<span lang="EN-US" style="white-space:normal;font-family:Verdana;">The benzodiazepines were introduced into medical practice during the 1960s. At the time, they represented a safer alternative to extant therapies used for anxiety, such as the barbiturates. However, on September 23, 2020, the United States FDA indicated that more is needed to be known about the initiation, continuation, and discontinuation of </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">the </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">us</span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">e of</span><span lang="EN-US" style="white-space:normal;font-family:Verdana;"> these widely-used drugs with publication of the announcement </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">“</span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">to address the serious risks of abuse, addiction, physical dependence, and withdrawal reactions, the U.S. Food and Drug Administration (FDA) is requiring the Boxed Warning be updated for all benzodiazepine medicines.</span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">”</span><span lang="EN-US" style="white-space:normal;font-family:Verdana;"> Because for many years</span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">, </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">there has been a sparsity </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">of </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">research on these drugs, relevant information is unfortunately lacking at this critical time. It is therefore valuable to (re)establish animal models and begin to collect relevant data. We here use a model of conditioned place</span><span lang="EN-US" style="white-space:normal;" "=""> </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">preference (CPP) </span><span lang="EN-U<span lang="EN-US" style="white-space:normal;font-family:Verdana;">The benzodiazepines were introduced into medical practice during the 1960s. At the time, they represented a safer alternative to extant therapies used for anxiety, such as the barbiturates. However, on September 23, 2020, the United States FDA indicated that more is needed to be known about the initiation, continuation, and discontinuation of </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">the </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">us</span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">e of</span><span lang="EN-US" style="white-space:normal;font-family:Verdana;"> these widely-used drugs with publication of the announcement </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">“</span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">to address the serious risks of abuse, addiction, physical dependence, and withdrawal reactions, the U.S. Food and Drug Administration (FDA) is requiring the Boxed Warning be updated for all benzodiazepine medicines.</span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">”</span><span lang="EN-US" style="white-space:normal;font-family:Verdana;"> Because for many years</span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">, </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">there has been a sparsity </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">of </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">research on these drugs, relevant information is unfortunately lacking at this critical time. It is therefore valuable to (re)establish animal models and begin to collect relevant data. We here use a model of conditioned place</span><span lang="EN-US" style="white-space:normal;" "=""> </span><span lang="EN-US" style="white-space:normal;font-family:Verdana;">preference (CPP) </span><span lang="EN-U

关 键 词：BENZODIAZEPINE Conditioned Placepreference ALPRAZOLAM Female Rats 

分 类 号：O17[理学—数学]