Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods  

作　　者：Yi-Xin Zhang Yuan Zhang Yu Bian Ya-jie Liu Ai Ren Yu Zhou Du Shi Xue-Song Feng 

机构地区：[1]School of Pharmacy,China Medical University,Shenyang,110122,China [2]Department of Pharmacy National Cancer Center/National Clinical Research Centerfor Cancer/Cancer Hospital,ChineseAcademy of Medical Sciences and Peking Union Medical College,Beijing,100021,China [3]Department of Urology,The First Hospital of China Medical University,Shenyang,110001,China

出　　处：《Journal of Pharmaceutical Analysis》2023年第5期442-462,共21页药物分析学报（英文版）

基　　金：supported by the Scientific Research Project of the Department of Education of Liaoning Province,China(Grant No.:ZF2019036).

摘　　要：Benzodiazepines(BDZs)are used in clinics for anxiolysis,anticonvulsants,sedative hypnosis,and muscle relaxation.They have high consumptions worldwide because of their easy availability and potential addiction.They are often used for suicide or criminal practices such as abduction and drug-facilitated sexual assault.The pharmacological effects of using small doses of BDZs and their detections from complex biological matrices are challenging.Efficient pretreatment methods followed by accurate and sensitive detections are necessary.Herein,pretreatment methods for the extraction,enrichment,and preconcentration of BDZs as well as the strategies for their screening,identification,and quantitation developed in the past five years have been reviewed.Moreover,recent advances in various methods are summarized.Characteristics and advantages of each method are encompassed.Future directions of the pretreatment and detection methods for BDZs are also reviewed.

关 键 词：BENZODIAZEPINE Biological matrices Detectionmethods Samplepreparation 

分 类 号：R927[医药卫生—药学]