Pilot Studies on the Novel Hypothesis that TSPO (Peripheral Benzodiazepine Receptor) Is Involved in Benzodiazepine/“Z-Drug” Physical Dependence and/or Withdrawal  

作　　者：Cheyenne Moffett Katherine J. Kost Austen Thompson Joseph V. Pergolizzi Jr. Tally M. Largent-Milnes Robert B. Raffa Todd Vanderah Cheyenne Moffett;Katherine J. Kost;Austen Thompson;Joseph V. Pergolizzi Jr.;Tally M. Largent-Milnes;Robert B. Raffa;Todd Vanderah(Department of Pharmacology, and Comprehensive Pain and Addiction Center, University of Arizona, Tucson, AZ, USA;NEMA Inc., Naples, FL, USA;Neumentum Inc., Summit, NJ, USA;Enalare Therapeutics, Naples, FL, USA;School of Pharmacy, Temple University, Philadelphia, PA, USA;College of Pharmacy (Adjunct), University of Arizona, Tucson, AZ, USA)

机构地区：[1]Department of Pharmacology, and Comprehensive Pain and Addiction Center, University of Arizona, Tucson, AZ, USA [2]NEMA Inc., Naples, FL, USA [3]Neumentum Inc., Summit, NJ, USA [4]Enalare Therapeutics, Naples, FL, USA [5]School of Pharmacy, Temple University, Philadelphia, PA, USA [6]College of Pharmacy (Adjunct), University of Arizona, Tucson, AZ, USA

出　　处：《Pharmacology & Pharmacy》2023年第3期72-83,共12页药理与制药（英文）

摘　　要：Benzodiazepines and other benzodiazepine receptor agonists, such as the “Z” drugs, are widely prescribed medications mainly used for treating anxiety and seizures, and for inducing sedation. Unfortunately, despite their popularity, benzodiazepine prescribing often exceeds recommendations and the consequences can be severe. On September 23, 2020, the United States FDA announced a new requirement for a Boxed Warning for benzodiazepines prescribing. Along with this announcement, the FDA stated that relevant information regarding the initiation, continuation, and discontinuation of benzodiazepines is lacking. Here, we describe initial pilot studies intended to investigate the questions 1) can animal models be developed that demonstrate benzodiazepine physical dependence and/or withdrawal symptoms, and 2) determine whether translocator protein (TSPO) plays a role in benzodiazepine dependence and/or withdrawal processes. The former was demonstrated, methodological limitations prevented the latter.Benzodiazepines and other benzodiazepine receptor agonists, such as the “Z” drugs, are widely prescribed medications mainly used for treating anxiety and seizures, and for inducing sedation. Unfortunately, despite their popularity, benzodiazepine prescribing often exceeds recommendations and the consequences can be severe. On September 23, 2020, the United States FDA announced a new requirement for a Boxed Warning for benzodiazepines prescribing. Along with this announcement, the FDA stated that relevant information regarding the initiation, continuation, and discontinuation of benzodiazepines is lacking. Here, we describe initial pilot studies intended to investigate the questions 1) can animal models be developed that demonstrate benzodiazepine physical dependence and/or withdrawal symptoms, and 2) determine whether translocator protein (TSPO) plays a role in benzodiazepine dependence and/or withdrawal processes. The former was demonstrated, methodological limitations prevented the latter.

关 键 词：BENZODIAZEPINE TSPO Rats In Vivo Tests Western-Blot Analysis 

分 类 号：F20[经济管理—国民经济]