氟西汀对乳腺癌抑郁症患者的干预效果(英文)  

Interventional effect of fluoxetine on the quality of life in depressive patients with breast cancer

作　　者：汤艳清[1] 丁宝坤[1] 李艳苓[2] 

机构地区：[1]中国医科大学医学心理学和精神医学教研室,辽宁省沈阳市110001 [2]鞍山市中心医院心理科,辽宁省鞍山市116001

出　　处：《中国临床康复》2005年第8期216-217,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:目前国内外对于乳腺癌生活质量的研究较多,但抗抑郁药对于乳腺癌抑郁症患者生活质量的影响还不清楚。目的:探讨氟西汀对乳腺癌抑郁症患者生活质量的影响。设计:以患者为研究对象,前后对照的观察对比研究。单位:两所大学医学心理学和精神医学专业研究机构和一所市级医院的心理科。对象:中国医科大学附属第一医院、中国医科大学附属第二医院和大连市肿瘤医院住院的乳腺癌术后患者63例,平均(50±9)岁。干预:对63例乳腺癌抑郁症患者进行8周的氟西汀治疗,采用副反应量表(TESS)和相关实验室检查评价氟西汀对乳腺癌抑郁症患者抑郁、焦虑的安全性,采用世界卫生组织生存质量评定量表(WHOQOL)评价患者用药前后的生活质量。主要观察指标:①WHOQOL各项指标评分。②副作用及不良反应。结果:用药8周后患者生活质量中的生理(16.30±2.17)、心理(14.41±1.85)、独立性(16.90±1.53)三个领域评分明显高于入组前(13.61±2.46,12.98±2.65,13.65±2.45),差异有显著性意义(t=6.52,P<0.01;t=2.41,P<0.05和t=8.93,P<0.01)。患者用药期间未出现明显药物副反应。结论:氟西汀能明显改善乳腺癌患者的生活质量。BACKGROUND:There are many studies on the quality of life (QOL) of patients with breast cancer at home and abroad at present. But the effect of antidepressants on the QOL of depressive patients with breast cancer is not clear yet. OBJECTIVE:To investigate the effect of fluoxetine on the QOL of depressive patients with breast cancer. DESIGN:A self-controlled and observational comparative study of taking the patient as the subjects. SETTING:The research institute of medical psychology and psychiatric specialty in two universities and a psychiatric department in a city hospital. PARTICIPANTS:Sixty-three female post-operative patients with breast cancer hospitalized in the First Affiliated Hospital and Second Affiliated Hospital of China Medical University and Dalian Tumor Hospital,with an average age of (50±9) years. INTERVENTIONS:Sity-three depressive patients with breast cancer were treated with fluoxetine for 8 weeks.Treatment emergent symptom scale(TESS) and relative laboratory examinations were used to evaluate the safety of fluoxetine to depression and anxiety of depressive patients with breast cancer.QOL of WHO scale was used to assess the QOL of the patients before and after administration. MAIN OUTCOME MEASURES:①Score of every index of QOL of WHO;②Side effects and adverse effects. RESULTS:The scores of physiology,psychology and independence in QOL after 8 weeks' administration(16.30±2.17,14.41±1.85,16.90±1.53) were significantly higher than those before grouping (13.61±2.46,12.98±2.65,13.65±2.45)(t=6.52,P< 0.01;t=2.41,P < 0.05;t=8.93,P< 0.01).No obvious side effect was observed during administration. CONCLUSION:Fluoxetine can significantly improve the QOL of patients with breast cancer and there are fewer side effects during the treatment.

关 键 词：氟西汀 乳腺癌 抑郁症 干预 

分 类 号：R749.29[医药卫生—神经病学与精神病学]