女性吸毒者吸毒特点与乙型及丙型肝炎病毒重叠感染的关系(英文)  

Relationship between characteristics of drug using in female drug users and double infection of hepatitis B virus and hepatitis C virus

作　　者：刘春 黄民主[2] 关岚[2] 刘浩[2] 

机构地区：[1]深圳市人民医院检验科,广东省深圳市518010 [2]中南大学公共卫生学院流行病学教研室,湖南省长沙市410078

出　　处：《中国临床康复》2005年第8期250-251,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:吸毒行为是吸毒者感染乙型肝炎病毒(hepatitisBvirus,HBV)和丙型肝炎病毒(hepatitisCvirus,HCV)感染的主要原因,女性吸毒者吸毒行为有其自身特点,这些特点与HBV,HCV重叠感染有何关系?目的:了解不同吸毒特点与女性吸毒者HBV,HCV重叠感染率的关系。设计:2002-01进行的以女性吸毒者为研究对象的横断面调查。单位:一所市级医院检验科,一所大学的公共卫生学院流行病学教研究室,一所专业戒毒所。对象:整群抽取株洲市白马垅戒毒所320名女性吸毒人员为调查对象。方法:用自编问卷调查吸毒者吸毒特点,用ELISA法测定其血清中乙型肝炎病毒表面抗原(HBsAg)及抗丙型肝炎病毒抗体(抗-HCV)。主要观察指标:吸毒者HBV,HCV重叠感染与注射吸毒、吸毒年限、吸毒时间、戒毒次数之间的关系。结果:320份血清HBsAg和抗-HCV重叠感染率9.37%,全部为注射毒品者,与非注射吸毒者比较,差异有显著性(χ2=6.276,P<0.05);吸毒年限越长,重叠感染率越高,吸毒时间1～5年与5～10年组的重叠感染率(4.5%和10.3%)差异有显著性(χ2=8.344,P<0.05);戒毒次数≤3次与戒毒次数≥4次的重叠感染率差异有显著性(χ2=9.418,P<0.05);吸毒年限、戒毒次数是影响女性吸毒者HBV、HCV重叠感染的主要因素(OR=1.923,1.597;95%CI=0.964～3.838,0.962～2.652)。?BACKGROUND:Drug use is the most significant risk factor for viral hepatitis B and C infection.Female drug users present different drug-using characteristics from the other sex.And what about the influence of these characteristics on hepatitis B and C virus(HBV and HCV) double infection? OBJECTIVE:To explore the relationship of characteristics of drug using in female drug users on the incidence of HBV and HCV double infection. DESIGN:It is a cross section investigation of female drug users in January 2002. SETTING:A laboratory separtment,an epidemiological department in a university and a drug dependency treatment unit. PARTICIPANTS:A total of 320 female drug users who were in Baimalong drug dependency treatment unit in Zhuzhou city were recruited in this study. METHODS:The drug-using characteristics were investigated through a questionnaire and the surface antigen of HBV(HBsAg)and antibody against HCV(anti-HCV)in serum were checked with ELISA. MAIN OUTCOME MEASURES:Relationship between HBV and HCV infection and injection of drug,injecting career and abstaining history. RESULTS:The incidence of HBV and HCV double infection in the 320 female drug users was 9.37%.All of those with double infection were injection drug users,which was different from non-injection drug users(χ2=6.276,P< 0.05).Longer career of drug-using meant higher possibility of double infection.The incidence of double infection (10.3%) in those of 5-10 years of drug-using career was higher than that (4.5%) of 1-5 years of drug-using career (χ2=8.344,P< 0.05). And that in those experienced more than 4 times of abstaining was also higher than that less than in those experienced 3 times (χ2=9.418,P< 0.05).Long career of drug using and repeated abstention abstaining were factors that leaded to HBV and HCV double infection(OR=1.923,1.597,95%CI=0.964-3.838,0.962-2.652). CONCLUSION:Injection drug use is the predominant factor that causes double infection of HBV and HCV and long career of drug using and rising in the number of times of abstain

关 键 词：物质相关性障碍 女(雌)性 肝炎 乙型 肝炎 丙型 重叠感染 

分 类 号：R749[医药卫生—神经病学与精神病学]