甲基强的松龙与地塞米松治疗重症毛细支气管炎的疗效与安全性研究  

Effect of methylprednisolone and dexamethasone on the patients with serious bronchiolitis

作　　者：孔令侠[1] 张宝华[1] 褚福明[1] 刘红[1] 李艳[1] 

机构地区：[1]滕州市中心人民医院,山东滕州277500

出　　处：《山东医药》2005年第4期8-9,共2页Shandong Medical Journal

基　　金：枣庄市科技局鉴定(枣科成鉴字2004第632号)

摘　　要：目的　观察甲基强的松龙与地塞米松治疗重症毛细支气管炎的疗效及其白介素 (IL) - 2、IL- 4、干扰素 γ(IFNγ)、生长激素 (GH)、白蛋白 (A)、球蛋白 (G)、白蛋白 /球蛋白 (A/ G)的变化。方法　将 16 0例重症毛细支气管炎患儿分为甲基强的松龙组 84例及地塞米松组 76例 ,观察两组喘憋、哮鸣音消失和住院时间 ,以及治疗前后 IL - 2、IL - 4、IFNγ、GH、A、G、A/ G。结果　甲基强地松龙组喘憋、哮鸣音消失和住院时间比地塞米松组缩短 (P<0 .0 1) ,IL - 4比治疗前明显降低 (P<0 .0 1)。结论　甲基强的松龙可通过调节免疫功能治疗重症毛细支气管炎。Objective To observe the therapeutic effect of methylpredni solone and dexamethasone on the patients with serious bronchiolitis,and to exam ine the change in IL-2,IL-4,IFNγ,growth hormone(GF),albumin(A),gl obulin(G),and the ratio of albumin to globulin(A/G) in serum.Methods 160 patients with serious bron chiolitis were randomly divided into two groups,84 patients treated w ith methylprednisolone (group M),76 patients treated with dexamethasone (gro up D) meanwhile,52 matched normal persons were refined to as control group.IL -2,IL-4,IFNγ,GF,A,G and A/G in control group,group M,group D ware exami ned before and after treatmen t respectively.In the meantime,rhonchi period and hospitalised period were reco rded. Result Rhonchi period and hospitalised period were sign ificantly shorter in grou p M than those in group D (P<0.01).Meanwhile the dec rease in the concentrati on of IL-4 after treatment was more evident than that before treatment ( P<0.001),while the features mentioned above were not changed significantly (P>0.05).Conclusi on Serious bronchiolitis can be treated with methylprednisolone via immune adjustment.

关 键 词：重症毛细支气管炎 甲基强的松龙 治疗 地塞米松 IL-4 住院时间 IFNΓ 目的观 结论 安全性研究 

分 类 号：R725[医药卫生—儿科] R735.7[医药卫生—临床医学]