胰腺癌术后预后因素的探讨  

PROGNOSIS FACTORS OF PANCREATIC CANCER AFTER OPERATION

作　　者：唐瑞峰[1] 张风瑞[1] 彭利[1] 王顺祥[1] 肖燕[1] 

机构地区：[1]河北医科大学第四医院,石家庄050011

出　　处：《肝胆外科杂志》2005年第1期21-23,共3页Journal of Hepatobiliary Surgery

摘　　要：目的　探讨胰腺癌术后影响预后的因素。方法　回顾分析 72例行手术治疗的胰腺癌病人的临床病理特点、手术方式和术后化疗效果 ,分析术后生存时间之间的差异。结果　 72例胰腺癌病人 ,淋巴结无转移组与淋巴结转移组相比较 ,前者的生存率显著增高 (P<0 .0 5 ) ;同样 ,无远隔脏器转移组、肿瘤细胞呈高分化组、行根治术组、术后化疗组与他们各自对照组相比较 ,生存率均显著增高 (P<0 .0 5 ) ,而且在进展期癌也得到相同结果 ;但肿瘤大小与生存率无差异 (P=0 .2 193)。结论　有无淋巴结转移和远隔脏器转移、肿瘤细胞的分化度是判断胰腺癌术后预后的重要因素 。Objective To discuss the prognosis factors of pancreatic cancer after operation.Methods Seventy-two patients with pancreatic cancer who underwent resection were reviewed regarding the clinicopathological characteristics, methods of resection and the effect of chemotherapy after operation. Survival time of the patients were analyzed by Kaplan-Meier, log-rank test.Result In 72 patients with pancreatic cancer, the survival rate was higher in 36 cases without lymph node metastasis than that in 36 cases with lymph node metastasis(P=0.0018), and it was higher in 58 cases without distant metastasis than that in 14 cases with distant metastasis(P=0.0062), and in 33 cases with tumor cells in well differentiation than that in 39 cases with tumor cells in middle and poor differentiation(P=0.0091), and in 20 cases with radical resection than that in 52 cases with no radical resection(P=0.0011), and in 54 cases with chemotherapy after resection than that in 18 cases without chemotherapy after resection(P<0.0001). However, it was not associated with the size of tumor(P=0.2193).Conclusion Lymph node state, distant metastasis and differentiation degree of tumor cells were definitive factors of the prognosis of patients with pancreatic cancer after surgery; Radical resection and chemotherapy after operation may prolong survival time of the patient.

关 键 词：胰腺癌 临床病理特点 手术 化疗 预后 

分 类 号：R576[医药卫生—消化系统]