针刺神门穴对阿尔茨海默病患者脑功能磁共振成像的影响  

Acupuncture at shenmen acupoint for brain functional MRI of patients with Alzheimer disease

作　　者：付平[1] 贾建平[1] 王敏[1] 

机构地区：[1]首都医科大学宣武医院神经内科,北京市100053

出　　处：《中国临床康复》2005年第1期120-121,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:应用脑功能磁共振成像技术观察针刺神门穴对阿尔茨海默病(Alzheimerdisease,AD)患者脑功能区的激活作用,探讨针刺治疗AD的客观基础。方法:对2004-03/08宣武医院收治的6例轻中度老年性痴呆患者进行的电针刺激神门穴,运用1.5T磁共振成像系统,采集脑部的fMRI数据,通过SPM软件分析,获取脑内不同区域的功能活动图像。结果:针刺神门穴主要引起老年性痴呆患者针刺对侧大脑皮质的功能活动,具体表现为左侧的额中回、颞上回、颞横回及中央前、后回,还有丘脑和壳核;另外,右侧额中回和颞上回也被激活。结论:针刺神门穴引起的脑部功能活动不仅与感觉运动中枢神经系统有关,而且还与认知功能有关,提示应用神门穴治疗老年性痴呆存在一定的客观基础。AIM: observe the effect of acupuncture at shenmen(HT 7) in activating the brai n functional region of patients with Alzheimer disease(AD) with brain functional MRI(fMRI),and probe into the impersonal basis of acupuncture for treating AD. METHODS:Six patients with mild to moderate AD admitted in Xuanwu Hospital betw een March 2004 and August 2004 were treated with electroacupuncture at shenmen(H T 7).The data of fMRI were collected on 1.5 T MRI systems and analyzed by Statis tical Parametric Mapping software to obtain the activation maps of brain functio n. RESULTS:The major role of acupuncture at shenmen(HT 7) was to activate the fun ctional area of contralateral cortex,including left middle frontal gyrus,superi or temporal gyrus,transverse temporal gyrus,precentral gyrus and postcentral g yrus,thalamus,and putamen. In addition,there was other activation in right mid dle frontal gyrus and superior temporal gyrus. CONCLUSION:The different areas of cerebral cortices activated by acupuncture a t shenmen(HT 7) have close correlation with sensory motor central nervous syste m and cognitive function,indicating the objective foundation that acupuncture at shenmen(HT 7) can play an important role in treatment of senile dementia.

关 键 词：痴呆 磁共振成像/针灸疗法 神门 电针疗法 

分 类 号：R749.1[医药卫生—神经病学与精神病学]