胚胎发育过程中神经节细胞发育和定位与胶质细胞源性神经营养因子/受体酪氨酸激酶信号传递系统的相关性  

Correlation between the development and location of ganglion cell during the emb ryogenesis and glial cell line derived neurotrophic factor/ the signal transduc tion system of receptor protein tyrosine kinase

作　　者：陆珊[1] 王蓬文[2] 

机构地区：[1]首都医科大学,北京市100054 [2]首都医科大学病理学教研室,北京市100054

出　　处：《中国临床康复》2005年第1期149-151,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:胶质细胞源性神经营养因子(glialcellline-derivedneurotrophicfactor,GDNF)/受体酪氨酸激酶Ret信号传递系统功能异常及基因变()异可导致肠道神经元缺失,从而引起先天性巨结肠(hirschsprung,HSCR的发生。综合GDNF/Ret信号传递系统与胚胎神经系统发育的)研究结果,探讨胚胎发育过程中神经节细胞的发育和定位的分子机制。资料来源:应用计算机检索Medline数据库1980-01/2004-06期间的有关Ret、GDNF及胚胎神经系统发育的文章,检索词“Ret,GDNF,neu-rons,nervoussystem,embryodevelopment,限定文章语言种类为英文。同时计算机检索中国期刊全文数据库和中国临床康复杂志1990-01/《》2004-06期间的相关文章,检索词Ret,GDNF,神经元,神经系统,胚胎发育,限定文章语言种类为中文。研究对象为GDNF/Ret信号传递系统功能异常及基因变异的患者和实验动物。资料选择:对资料进行初审,选取关于Ret,GDNF及胚胎神经系统发育的文献,查找全文,以随机对照试验为(RCT)纳入标准。资料提炼:共收集到45篇关于Ret,GDNF的功能及其与神经系统发育关系的文献。37篇文献符合纳入标准,排除8篇文章为非随机及重复的研究原著及综述。资料综合:综合以上研究结果说明,RET是一种原癌基因,其编码蛋白为受体酪氨酸激酶Ret。肠道神经节细胞的?OBJECTIVE:The deletion of intestinal neuron was induced by the disfunction of glial cell line derived neurotrophic factor(GDNF) / the signal transduction sys tem of receptor protein tyrosine kinase(Ret),and the genetic variation,which cou ld cause the occurrence of Hirschsprung's disease(HSCR).The results of the signa l transduction system of GDNF/Ret and the neurological development of embryo wer e synthetized in order to investigate the molecular mechanism in the development and location of the ganglion cells during the embryogenesis. DATA SOURCES:Using the key terms “Ret,GDNF,neurons,nervous system and embryo development”,we searched the MEDLINE database plus relevant reference checks of all articles on Ret,GDNF and the neurological development of embryo in English language between January 1980 and June 2004.Meanwhile,using the above key terms in Chinese,we searched the Chinese journals full text database and Chinese Jour nal of Clinical Rehabilitation in Chinese language between January 1990 and June 2004.The subjects were patients and experimental animal with the disfunction of GDNF/Ret signal transduction system and the genetic variation. STUDY SELECTION:All articles were selected firstly,those were relevant to Ret, GDNF and the neurological development of embryo were selected,and the full text was looked up.The randomized controlled trials(RCT) were accepted as inclusive c riteria. DATA EXTRACTION:A total of 45 articles were collected,which were relevant to R et,GDNF and neurological development.Among them,37 articles met inclusion criter ia,and 8 articles were excluded because of the non randomized trials and the du plicated summarizations. DATA SYNTHESIS:The research results showed that RET was a kind of original onc ogene,whose encoded protein was receptor protein tyrosine kinase Ret.Ret could r eceive signals to maintain the proliferation,movement and location of enteric ga nglion cells.The malfunction of Ret could cause the abnormal differentiation of enteric ganglion cells.GDNF p

关 键 词：受体蛋白质酪氨酸激酶 神经组织蛋白质类 肠神经系统/胚胎学 

分 类 号：R74[医药卫生—神经病学与精神病学]