C反应蛋白和纤维蛋白原对脑梗死患者预后判定的比较(英文)  

Comparison of values of C-reactive protein and fibrinogen in evaluating prognos is of cerebral infarction

作　　者：肖伟忠[1,2] 姚琳 孙圣刚[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院神经内科 [2]上海市南汇区中心医院内三科,上海市201300 [3]兰州市第三人民医院精神科

出　　处：《中国临床康复》2005年第1期225-227,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:众多研究表明C反应蛋白(C-reactiveprotein,CRP)对心肌梗死患者预后有很高的判定价值,但对缺血性脑卒中预后判定是否有同样的价值目前尚无定论。目的:探讨和比较CRP和纤维蛋白原(fibrinogen,FIB)对脑梗死预后判定的价值。设计:以诊断为依据,病例对照研究。地点和对象:全部患者均来自兰州医学院第二附属医院神经内科,94例脑梗死患者,男58例,女36例,平均年龄(58±11)岁。干预:采用免疫浊度法测定空腹状态下血浆中CRP和FIB水平,试剂盒由福建太阳生物技术公司提供,发病后3d评估患者的神经功能缺失评分,随访3个月统计脑梗死患者的残疾率、病死率。主要观察指标:脑梗死患者神经功能缺失评分、残疾率、病死率。结果:根据血中CRP水平,将脑梗死患者分为高CRP组和低CRP组;根据血中FIB水平,将脑梗死患者分为高FIB组和低FIB组。高CRP组脑梗死患者神经功能缺失评分(18.12±8.96)分,残疾率74%(40/54),病死率20%(11/54);低CRP组分别为(10.52±4.42)分,38%(15/40),5%(2/40)。高CRP组显著高于低CRP组t=3.82,χ2=12.66,4.56,P<0.001)(。高FIB组脑梗死患者神经功能缺失评分(17.69±5.12)分,残疾率70%(35/50);低FIB组分别为(14.32±4.65)分,45%(20/44),高FIB组显著高于低FIB组(t=2.19,χ=7.1,P<0.001)。BACKGROUND:Many studies indicate that the serum level of C reactive protein(C RP) has a great value in the prediction of myocardial infarction prognosis.Howev er,it remains uncertain whether CRP has the same value in predicting the prognos is of cerebral infarction. OBJECTIVE:To explore and compare the clinical value of CRP and fibrinogen(FIB) in evaluating the prognosis of cerebral infarction. DESIGN:A case control study based on diagnosis. SETTING and PARTICIPANTS:All the 94 patients with cerebral infarction came fro m the Neurology Department of Second Affiliated Hospital,Lanzhou Medical College .There were 58 males and 36 females,with an average age of(58±11) years old. INTERVENTIONS:Levels of fasting CRP and FIB in the plasm were measured with im munoturbidity assay.The reagent kits were produced by Fujian Sun Biological Tech nology Corporation.The scores of neurological deficit of the patients were worke d out within 3 days of onset, and disability rate and fatality rate were added u p at the third month of the follow up. MAIN OUTCOME MEASURES:The neurologic deficit score (NDS),disability rate and f atality rate of the patients with cerebral infarction. RESULTS:The patients were divided into different groups according to CRP and F IB levels,which were high CRP group,low CRP group, high FIB group and low FIB gr oup.NDS,disability rate and fatality rate in high CRP group [(18.12±8.96) point s,74%(40/54), and 20%(11/54),respectively] were significantly higher than thos e in low CRP group[(10.52±4.42) points,38%(15/40) and 5%(2/40),respectively]( t=3.82,χ2=12.66,4.56,P< 0.001). Similarly,NDS and disability rate in high FIB g roup [(17.69±5.12) points and 70%(35/50), respectively]were significantly high er than those in low FIB group[(14.32±4.65) points and 45%(20/44),respectively ](t=2.19,χ2=7.1,P< 0.001) while the fatality rate of the two groups was not sig nificantly different.CRP level had significant correlations with NDS,disability rate and fatality rate in the patients with cerebral infa

关 键 词：曼反应蛋白质 纤维蛋白原 脑梗塞 预后 

分 类 号：R743[医药卫生—神经病学与精神病学]