STAT3信号转导系统介导了CNTF对大鼠尾壳核出血后的神经保护作用  

EFFECT CILIARY NEUROTROPHIC FACTOR ON STAT3 LEVEL IN HIPPOCAMPUSOF RATS WITH PUTAMEN HEMORRHAGE

作　　者：张蕲[1] 张迎春[1] 廖晓梅[1] 田青[1] 胡茂琼[2] 王建枝[1] 

机构地区：[1]华中科技大学同济医学院病理生理系,武汉430030 [2]黄石理工学院医学系,黄石435001

出　　处：《中国组织化学与细胞化学杂志》2004年第4期531-534,共4页Chinese Journal of Histochemistry and Cytochemistry

基　　金：国家自然科学基金(30370560;39925012;30100057;30170221)

摘　　要：目的研究睫状神经生长因子(CNTF)在中枢神经元抗损伤中的作用及机制。方法对尾壳核出血大鼠进行CNTF治疗,观察海马信号转导和转录激活蛋白3(STAT3)含量及阳性神经元分布的变化。结果CNTF能显著增加尾壳核出血大鼠海马STAT3阳性神经元数量、海马STAT3含量。结论CNTF能通过促进STAT3的表达增强中枢神经元的抗损伤能力。? Objective To investigate the role of ciliary neurotrophic factor (CNTF) in injury of central neuron. Methods Treat the rats of putamen hemorrhagewith CNTF and detect the signal transducer and activator of transcription 3 (STAT3) level , the number and distribution of STAT3 labled neuron in hippocampusof rats withputamen hemorrhage. Results CNTF significantly increased the STAT3 level and the number of STAT3 labled neuron in hippocampusof rats withputamen hemorrhage. Conclusion CNTF protects central neuron away from injury by facilitating the expression of STAT3. 〔

关 键 词：CNTF STAT3 脑出血 

分 类 号：R741.02[医药卫生—神经病学与精神病学]