恶性黑色素瘤浸润转移相关分子机制研究  

Study on the Molecular-Mechanism of Invasion and Metastasis in Malignant Melanoma

作　　者：张诗武[1] 孙保存[1] 赵秀兰[2] 刘岩雪[1] 郝希山[1] 

机构地区：[1]天津医科大学附属肿瘤医院肿瘤研究所,300060 [2]天津医科大学病理教研室

出　　处：《天津医药》2005年第2期65-67,共3页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(项目编号:30070378)

摘　　要：目的:探讨MMP-2、MMP-9、TIMP-2、E-cadherin在高、低恶性黑色素瘤中浸润转移中的作用。方法:将临床资料完整的恶性黑色素瘤样本60例,按CK8、CK18染色结果分为高度恶性和低度恶性2组,并进行MMP-2、MMP-9、TIMP-2、E-cadherin免疫组化染色。结果:高度恶性组黑色素瘤MMP-2、TIMP-2的表达高于低度恶性组黑色素瘤的表达,低度恶性组黑色素瘤MMP-9、E-cadherin的表达高于高度恶性组,其中低度恶性组黑色素瘤MMP-9的表达结果同高度恶性组黑色素瘤的表达差别具有统计学意义(P<0.05)。结论:肿瘤浸润转移相关蛋白在不同肿瘤的浸润转移过程中作用各不相同,MMP-2、TIMP-2促进了肿瘤的浸润转移,而MMP-9、E-cadherin抑制肿瘤的转移。Objective: To study the effects of MMP-2, MMP-9, TIMP-2 and E-cadherin on invasion and metastasis in high and low grade malignant melanoma. Methods: Sixty cases with malignant melanoma were divided into high and low grade groups according to the immunohistochemical results of CK8, CK18, MMP-2, MMP-9, TIMP-2 and E-cadherin were detected by immunohistochemical staining. Results: Expressions of MMP-2 and TIMP-2 in high grade malignant melanoma group were higher than those in low grade group. Expressions of E-cadherin and MMP-9 in low-grade malignant melanoma group were higher than those in high grade group. There was statistical significance of MMP-9 expression between high and low grade malignant melanoma (P < 0.05). Conclusion: Proteins which are correlative with invasion and metastasis in tumors have different functions in different tumors. MMP-2 and TIMP-2 accelerate invasion and metastasis in tumors. MMP-9 and E-cadherin inhibit the process.

关 键 词：MMP-9 TIMP-2 低度恶性 MMP-2 恶性黑色素瘤 E-CADHERIN 浸润转移 结论 高度 过程 

分 类 号：R737[医药卫生—肿瘤] R739[医药卫生—临床医学]