人工肝治疗慢性重型肝炎的影响因素分析  

Analysis on the factors influencing the prognosis of chronic severe hepatitis treatment by artificial liver support system

作　　者：王海霞[1] 江元森[2] 谢俊强[2] 李学俊[2] 张绍全[2] 邓友[2] 

机构地区：[1]泰山医学院附属医院传染科,山东泰安271000 [2]中山大学附属第三医院传染科,广东广州510630

出　　处：《泰山医学院学报》2004年第5期415-417,共3页Journal of Taishan Medical College

摘　　要：目的　通过 6 5例人工肝治疗慢性重型肝炎的临床总结 ,探讨人工肝治疗慢性重型肝炎的影响因素。方法　对 6 5例人工肝治疗慢性重型肝炎临床资料进行回顾性分析。结果　病死率与年龄和性别无关 ;单独乙肝与重叠其他病毒感染无明显差异 ;病死组病人肝性脑病 (86 .4 9% )、肝肾综合征 (4 0 .5 4 % )、严重感染 (2 7.0 3% )及原发性腹膜炎 (6 4 .86 % )发生率明显高于好转或治愈组 (35 .71%、10 .71%、3.5 7%、39.2 9% ,P <0 .0 5 ) ;凝血酶原活动度 (2 6 .2 9± 13.75 )与胆固醇 (1.2 7± 0 .6 6 )明显低于好转或治愈组 (32 .937.38、2 .2 11.0 6 ,P <0 .0 5 )。结论　凝血酶原活动度与胆固醇降低、并发肝性脑病、肝肾综合征。Objective: To explore the prognostic factors on patients with chronic severe hepatitis treatment by artificial liver support system by analyzing the clinical date of 65 cases with chronic severe hepatitis treatment by artificial liver support system. Methods Clinical data of 65 patients with chronic severe hepatitis treatment by artificial liver support system were analyzed retrospectively. Results Fatality rate in patients with severe hepatitis had no relation to age and sexuality. There is no significant difference between the death rate of patients with single infection of HBV and that of patients with multiple infection of HBV and other type hepatitis virus. Hepatic encephalopathy (86.49%), hepatorenal syndrome(40.54%), severe infection(27.03%)and primary peritonitis (64.86%)in death group were higher than those in curing or improving group(35.71%, 10.71%, 3.57%, 39.29%, P<0.05)。.Prothrombrin activity (PTA) (26.29±13.75)and cholesterol (CHOL) (1.27±0.66) in death group was lower than that in curing or improving group(32.93±7.38, 2.21±1.06, P<0.05). Conclusion Low PTA, low CHOL, and complicated with hepatic encephalopathy, hepatorenal syndrome, severe infection and primary peritonitis are bad parameters in patients with chronic severe hepatitis treatment by artificial liver support system.

关 键 词：人工肝治疗 慢性重型肝炎 原发性腹膜炎 凝血酶原活动度 严重感染 肝性脑病 治愈 重叠 差异 目的 

分 类 号：R575.1[医药卫生—消化系统]