FK和EP方案治疗恶性滋养细胞肿瘤的疗效对比分析  

Comparartive Curative Effect between FK and EP Chemotherapy Scheme for the Treatment of Gestational Trophoblastic Neoplasms.

作　　者：王静[1] 汪楚英[1] 曹永涛[1] 卞文伟[1] 

机构地区：[1]江苏省连云港市肿瘤医院妇科,222023

出　　处：《湖北预防医学杂志》2003年第6期16-18,共3页Hubei Journal of Preventive Medicine

摘　　要：目的　与传统的 FK方案对比 ,观察 EP方案对恶性滋养细胞肿瘤的近期疗效、耐受性与毒副反应。方法　两方案分别治疗 30例患者。FK组 :5 -氟尿嘧啶和更生霉素静脉滴注 ,8天为 1疗程。EP组 :足叶乙甙和顺氯氨铂静脉滴注 ,5天为 1疗程。结果　 FK和 EP组治疗有效率分别为 90 .0 %和 96 .7% (P>0 .0 5 ) ;两组均有不同程度的毒副作用 ,白细胞减少发生率分别为 5 0 .0 %和 4 6 .6 % (P>0 .5 ) ;EP组口腔溃疡发生率为 6 .7% ,显著低于 FK组 4 0 .0 % (P<0 .0 1) ;腹泻发生率 FK组为 2 0 .0 % ,EP组无发生 (P<0 .0 5 )。结论　足叶乙甙和顺氯氨铂联合给药治疗恶性滋养细胞肿瘤的有效率与传统 FK方案对比无统计学差异 ,患者耐受良好 ,毒副反应较轻 ,值得进一步研究。Objective To observe the early efficacy, tolerance and complication of EP chemotherapy scheme in the treatment of gestational trophoblastic neoplasms, and compare with FK scheme.Methods 30 cases were treated by FK and EP chemotherapy schemes respectively. Group FK, 5-FU and KSM intravenous guttatim during a period of 8 days. Results The efficacy rate of group FK and group EP was 90.0% and 96 7% (P>0.05) respectively. There were certain side effects in both groups. The incidence rate of leukopenia was 50.0% and 46.6% (P>0.5) respectively. The incidence rate of stomatic ulcer was 6.7% (in group EP) and 40.0% ( in group FK) (P<0.01). The incidence rate of diarrhoea was 20.0% (in group FK) and 0% (in group EP) (P<0.05).Conclusion The effective rate of combined chemotherapy showed no significant difference with Vp-16 and DDP, as compared with FK scheme for the treatment of gestational trophoblastic neoplasms.Patients had good tolerance and milder side effect.

关 键 词：恶性滋养细胞肿瘤 抗癌药物 联合给药 疗效 

分 类 号：R7336[医药卫生—肿瘤]