Observation of the Ultrastructure in Syphilitic Chancres  

作　　者：张晓东 周晶 王德权 吴海燕 宋芳吉 

机构地区：[1]Department of Dermatology, No. 202 Hospital of P.L.A. [2]Department of Dermatology, No. 1 Hospital of China Medical University [3]Department of Urology,No. 202 Hospital of P.L.A [4]Department of Obstetrics & Gynecology,No.202 Hospital of P.L.A.

出　　处：《Chinese Journal of Sexually Transmitted Infections》2002年第1期31-34,共4页中华性传播感染杂志（英文版）

摘　　要：Objective: To study the occurrence and development ofprimary syphilis from a morphological and structural aspect.Method: The ultrastructural pathological changes of syphiliticchancre were examined by transmission electron microscopy(TEM). Results: The pathological changes of syphilitic chancreoccur mainly in the dermal layer, manifested as partialthinning or lysis of the capillary basal membrane,proliferation of capillary endothelial cells, thickening of somecollagen fibers and rupture of collagen fibers surrounding Tpallidum, structural disruption of the axons of terminal nerves,disarrangement of the sheath of the myelinated nerve fiberswith separation of laminae and the attachment of T pallidumon its outer membrane, appearance of slightly swollen Tpallidum in the plasma of the capillary endothelial cells andfibroblasts, and infiltration of neutrophils, macrophages andplasma cells containing T pallidum and its debris frequentlylined by a clear sheath. Conclusion: The pathogenesis and injury of mechanism inprimary syphilis can be explained morphologically by itscharacteristic ultrastructural pathological changes.Objective:To study the occurrence and development of primary syphilis from a morphological and structural aspect. Results: The pathological changes of syphilitic chancre occur mainly in the dermal layer, manifested as partial thinning or lysis of the capillary basal membrane, proliferation of capillary endothelial cells, thickening of some collagen fibers and rupture of collagen fibers surrounding T.pallidum, structural disruption of the axons of terminal nerves, disarrangement of the sheath of the myelinated nerve fibers with separation of laminae and the attachment of T. pallidum on its outer membrane, appearance of slightly swollen T.pallidum in the plasma of the capillary endothelial cells and fibroblasts, and infiltration of neutrophils, macrophages and plasma cells containing T. pallidum and its debris frequently lined by a clear sheath. Conclusion: The pathogenesis and injury of mechanism in primary syphilis can be explained morphologically by its characteristic ultrastructural pathological changes.

关 键 词：Syphilitic chancre Treponema pallidum MICROSCOPY ULTRASTRUCTURE transmission electron microscopy 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]