P^(53)基因在结一直肠癌组织中表达的研究  

Study of P5S Gene Expression in Tissues of Colorectal Cancer

作　　者：李向阳[1] 常鲜华[1] 张福国[1] 李森[1] 奚纯厚 

机构地区：[1]解放军第209医院病理科 [2]不详

出　　处：《牡丹江医学院学报》1994年第3期4-5,共2页Journal of Mudanjiang Medical University

摘　　要：本文应用鼠抗P^(53)单抗免疫组化技术,对50例结一直肠癌组织中P^(53)表达进行研究。结果表明在结一直肠癌组织中P^(53)表达阳性率为42％。在5例正常结肠组织中P^(53)表达均呈阴性,提示在直肠癌组织中P^(53)基因免疫活性增高而显示过度表达。P53染色均定注于癌细胞核内,其表达阳性率及阳性细胞核染色强度,在结一直肠癌不同组织学类型及分化程度中显示出一定差异,即分化程度越低、P^(53)表达阳性率越高,阳性细胞染色程度越强。P53 gene expression in tissues of colorectal cancer of 50 caseswas studied using monoclonal mouse anti-human P53 gene immuno-histochemical techniques. The results showed that positive rate of P53gene expression in tiSuSes of colorectal cancer waS 42%. P53 geneexpression in normal colonal tissues of 5 cases was nega tive. These Suggested that immunologic activation of P53 gene in ti ssues of colorectal cancer was increased and over expressive. P53 stain located in cell nuclei of ca ncer. Positive rate of P53 expression and strength of positive stain in cell nuclei were different in different histologic typies and differenciative degrees. The lower differenciative degree , the higher positive rate of P53 expression and the stronger stain degree of positive cell nuclei.

关 键 词：P^53基因 直肠癌 癌组织中 表达 阳性率 分化程度 阳性细胞 中正 表述 定位 

分 类 号：R735[医药卫生—肿瘤] R734.2[医药卫生—临床医学]