182例肺癌病人癌症家族史的分析  

Family history analysis of 182 cases lung cancer.

作　　者：许凤琴 张超[1] 胡承章[1] 谢翠鹏[1] 岳卫红 鲍云华 张东 隗铁夫 张京梅[1] 

机构地区：[1]航天部中心医院,中国医学科学院肿瘤医院,航天部711医院,中国人民解放军307医院

出　　处：《中国优生与遗传杂志》1994年第4期30-31,24,共3页Chinese Journal of Birth Health & Heredity

摘　　要：本文调查了１８２例肺癌病人及２００例非肿瘤病人（对照组）的癌症家族史，分析结果：①肺癌组家族患癌率为１９．２％，其中直系亲属占９４％，对照组家族患癌率为２０％，其中直系亲属占８５％，肺癌组直系亲属患癌比例大于对照组，提示：肺癌的发病与遗传因素可能有相关性。②将三种不同组织类型肺癌病人的家族患癌率作了比较，小细胞肺癌（Ｓｃｌｃ）组最高为２６．６％，其次是腺癌２１％，鳞癌最低为１０％，提示Ｓｃｌｃ很可能与癌遗传因素有关。We investigated the family history of 182 lung cancer patients and 200 non-cancer patients(for comparison).Results:1.Cancer morbidity among family members of the cancer group is 19.2%,in which the morb idity among the directly-related me mbers is 94%,cancer morbidity among family members of the non-cancer group is 20%,in which the morbidity among the directly-related members is 85%. The cancer morbidity among the directly-related members of the cancer group is higher than that of the non-cancer group.Though it shows no significance in statistics,it implicates the correlationship betw een morbidity and genetic factors.2.Comparison of the morbidity of the family members from the three types of lung cancer:family morbidity among small cell anaplastic carcinoma group is 26.6%,the highest family morbidity among adenocarcinoma group is 21%,the middle. Family morbidity among epidermoid carcinoma group is 10%,the lowest.It implicates genetic factors have direct bearing on the incidence of small cell anaplastic carcinoma.

关 键 词：肺癌 癌症家族史 非肿瘤病人 患癌率 遗传因素 

分 类 号：R734.2[医药卫生—肿瘤]