女性乳腺癌的遗传流行病学研究  

Genetic epidemiology study of female breast cancer.

作　　者：顾源[1] 施侣元[1] 詹卓玲[1] 张惠娟[1] 安莲珍 郑绍卿 袁俊[1] 尹祖善 

机构地区：[1]同济医科大学流行病学教研室,平顶山矿务局卫生处,湖北省肿瘤医院乳腺科,湖北省襄樊市卫生防疫站

出　　处：《中国优生与遗传杂志》1994年第6期62-64,共3页Chinese Journal of Birth Health & Heredity

摘　　要：本文应用遗传流行病学方法对５个城市居民中的２３０例女性乳腺癌患者及其４６０名对照进行了调查，结果表明：女性乳腺癌患者一级亲属的女性乳腺癌发病率（２．０６％）显著高于对照者一级亲属的发病率（０．２３％，ＲＲ＝９．０６，９５％，ＣＩ＝３．０７－２６．６８）；用Ｆａｌｃｏｎｅｒ阈值模型估算出女性乳腺癌一级亲属的遗传度为５０．６６±６．１６％；并用多因素条件Ｌｏｇｉｓｔｉｃ回归模型在控制可能的混杂因素条件下，分析了影响乳腺癌发病的主要危险因素，结果显示礼腺癌家族史仍为有意义的因素。本文结果提示遗传因素为影响乳腺癌发病的重要危险因素，并与有关环境危险因素拟存在一定联系。Genetic epidemiology method was used to investigate 230 women with breast cancer and 460 matched controls in five cities.The results indicated the incidence rates of female breast cancer in the first-degree relatives (2.06%) significantly higher than that of controls(0.23%). RR=9.06 95% CI=3.07-26.68.Estimated with Falconer'threshold model, the heritabilities(h2)of breast cancer for first degree relatives Were 50.66±0.16%.Adjustment for potential confounding varibles was carried out by conditional logistic model. Results suggest that risk of breast eancer is increased in the women with a family history of breast cancer(OR=2.35 95% CI=1.27-4.35).These results showed that genetic factor is an identified risk factor for breast cancer and they may play a role in association with enviromental risk factors.

关 键 词：乳腺癌 遗传流行病学 女性 一级亲属 发病 患者 危险因素 混杂因素 遗传度 联系 

分 类 号：R737.9[医药卫生—肿瘤] R587.1[医药卫生—临床医学]