硷式醋酸铅对化学致癌物诱发小鼠肺肿瘤的影响  

EFFECT OF BASIC LEAD ACETATE ON INDUCTION OF LUNG TUMORS IN MICE TREATED WITH CHEMICAL CARCINOGENS

作　　者：陈增良[1] 徐英含[1] 

机构地区：[1]浙江医科大学病理解剖学教研室

出　　处：《浙江医科大学学报》1993年第4期158-160,共3页

基　　金：国家自然科学基金

摘　　要：本文研究了硷式醋酸铅(BLA)对化学致癌物诱发小鼠肺肿瘤的影响。实验结果表明:①单纯BLA处理不能诱发小鼠肿瘤;②BLA对多种化学致癌物诱发小鼠肺肿瘤作用有不同效应。BLA明显促进二甲基亚硝胺(DMN)诱发小鼠肺肿瘤的发生率,增加每鼠平均肺肿瘤数;相反,氨基甲酸乙酯(EC)诱发小鼠肺肿瘤的作用则受抑制,使EC+BLA组小鼠肺肿瘤的平均瘤结数明显减少;BLA对甲基硝基亚硝基胍(MNNG)诱发小鼠肺肿瘤作用无明显影响。The effects of basic lead acetate (BLA) on the induction of lung tumors were studied in mice treated with chemical carcinogens. It was demonstrated that BLA enhanced the deve- lopment of lung tumors in mice treated with dimethylnitrosamine to thus raise the incidence in lung tumor-bearing mice and increase the average number of lung tumors in each mouse. On the contrary, the effect of BLA on chemical tumorigenesis was found in mice treated with urethan to decrease the average number of lung tumors in each mouse. But no significant dif- ference was observed between the mice treated with N-methyl-N-nitro-nitroso-guanidine (MNNG) and those with MNNG plus BLA. No tumor was found in mice treated with BLA alone under our experimental conditions.

关 键 词：铅 致癌物 肺肿瘤 化学诱导 

分 类 号：R734.202[医药卫生—肿瘤]